ShockOmics: Multiscale approach to the identification of molecular biomarkers in acute heart failure induced by shock

Federico Aletti, Costanza Conti, Manuela Ferrario, Vicent Ribas, Bernardo Bollen Pinto, Antoine Herpain, Emiel Post, Eduardo Romay Medina, Cristina Barlassina, Eliandre de Oliveira, Roberta Pastorelli, Gabriella Tedeschi, Giuseppe Ristagno, Fabio S. Taccone, Geert W. Schmid-Schönbein, Ricard Ferrer, Daniel De Backer, Karim Bendjelid, Giuseppe Baselli

Research output: Contribution to journalArticle

Abstract

Background: The ShockOmics study (ClinicalTrials.gov identifier NCT02141607) is a multicenter prospective observational trial aimed at identifying new biomarkers of acute heart failure in circulatory shock, by means of a multiscale analysis of blood samples and hemodynamic data from subjects with circulatory shock. Methods and Design: Ninety septic shock and cardiogenic shock patients will be recruited in three intensive care units (ICU) (Hôpital Erasme, Université Libre de Bruxelles, Belgium; Hospital Universitari Mutua Terrassa, Spain; Hôpitaux Universitaires de Genève, Switzerland). Hemodynamic signals will be recorded every day for up to seven days from shock diagnosis (time T0). Clinical data and blood samples will be collected for analysis at: i) T1 <16 h from T0; ii) T2 = 48 h after T0; iii) T3 = day 7 or before discharge or before discontinuation of therapy in case of fatal outcome; iv) T4 = day 100. Discussion: ShockOmics will provide new insights into the pathophysiological mechanisms underlying shock as well as new biomarkers for the timely diagnosis of cardiac dysfunction in shock and quantitative indices for assisting the therapeutic management of shock patients.

Original languageEnglish
JournalScandinavian Journal of Trauma, Resuscitation and Emergency Medicine
DOIs
Publication statusAccepted/In press - Jan 28 2016

Keywords

  • Acute heart failure
  • Biomarkers
  • Hemodynamics
  • Metabolomics
  • Multiscale modeling
  • Proteomics
  • Shock
  • Transcriptomics

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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    Aletti, F., Conti, C., Ferrario, M., Ribas, V., Bollen Pinto, B., Herpain, A., Post, E., Romay Medina, E., Barlassina, C., de Oliveira, E., Pastorelli, R., Tedeschi, G., Ristagno, G., Taccone, F. S., Schmid-Schönbein, G. W., Ferrer, R., De Backer, D., Bendjelid, K., & Baselli, G. (Accepted/In press). ShockOmics: Multiscale approach to the identification of molecular biomarkers in acute heart failure induced by shock. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. https://doi.org/10.1186/s13049-016-0197-4