Short- and long-term health related quality-of-life and anginal status of the Arterial Revascularisation Therapies Study part II, ARTS-II; sirolimus-eluting stents for the treatment of patients with multivessel coronary artery disease

Ron T. Van Domburg, Joost Daemen, Marie Claude Morice, Bernard De Bruyne, Antonio Colombo, Carlos Macaya, Gert Richardt, Jean Fajadet, Christian Hamm, Gerrit Anne Van Es, Kristel Wittebols, Nathalie Macours, Hans Peter Stoll, Patrick W. Serruys

Research output: Contribution to journalArticle

Abstract

Aims: Assessment of health related quality-of-life (HRQL) has become increasingly important as not only the clinician's view of the technical success, but also the patient's perception is being measured. We evaluated the HRQL following sirolimus-eluting coronary stent (SES) (CYPHER®; Cordis, Johnson & Johnson, Warren, NJ, USA) implantation in patients with multivessel disease, comparing the outcomes with the historical surgical and bare metal stent (BMS) arms of the ARTS-I study. Methods and results: The HRQL outcomes were compared to the outcome of the historical cohorts of the randomised ARTS-I trial using the same inclusion and exclusion criteria. HRQL was evaluated at baseline, at one month and at 6, 12 and 36 months after revascularisation using the SF-36 in patients treated with SES (n=585), BMS (n=483) or coronary artery bypass graft (CABG) (n=492). The HRQL compliance rates varied from 100% at baseline to 92% at 36 months. Both stenting and CABG resulted in significant improvement of HRQL and anginal status. There was a trend towards better HRQL after CABG than BMS beyond six months. Already from the first month up to three years, SES patients had, on average, 10% significantly better HRQL than BMS patients on the HRQL subscales physical functioning, role physical functioning, role emotional functioning and mental health (p

Original languageEnglish
Pages (from-to)962-967
Number of pages6
JournalEuroIntervention
Volume5
Issue number8
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Bare metal stent
  • Coronary artery bypass graft
  • Health related quality-of-life
  • Percutaneous coronary intervention
  • Sirolimus-eluting stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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    Van Domburg, R. T., Daemen, J., Morice, M. C., De Bruyne, B., Colombo, A., Macaya, C., Richardt, G., Fajadet, J., Hamm, C., Van Es, G. A., Wittebols, K., Macours, N., Stoll, H. P., & Serruys, P. W. (2010). Short- and long-term health related quality-of-life and anginal status of the Arterial Revascularisation Therapies Study part II, ARTS-II; sirolimus-eluting stents for the treatment of patients with multivessel coronary artery disease. EuroIntervention, 5(8), 962-967. https://doi.org/10.4244/EIJV5I8A161