Short- and long-term morbidity and mortality in the population exposed to dioxin after the "Seveso accident"

Angela Cecilia Pesatori, Dario Consonni, Silvia Bachetti, Carlo Zocchetti, Matteo Bonzini, Andrea Baccarelli, Pier Alberto Bertazzi

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

The early effects of 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) exposure in the population involved in the Seveso, Italy, incident in 1976, have been examined in numerous studies. Chloracne was the only effect linked with sufficient certainty to dioxin exposure. The possible long-term consequences were investigated with mortality and cancer incidence studies. Mortality and morbidity findings during the 20-year period following the accident showed increased risk from lymphoemopoietic neoplasm, digestive system cancer (rectum in males, and biliary tract among females, in particular) and respiratory system cancer (lung, among males). In the incidence analyses, also thyroid gland and pleura cancer appeared suggestively increased. Soft tissue sarcomas showed an increase in the largest, yet least exposed, exposure sub-cohort. Several hypotheses associating non-cancer effects with dioxin exposure were corroborated by findings in the Seveso population: this was the case with cardiovascular effects (possibly linked to both chemical exposure and stressful disaster experience), endocrine effects (diabetes among females) and reproductive effects: exposure of men to TCDD was linked to a lowered male/female sex ratio in their offspring. The results of many Seveso studies point to possible gender effects, in accordance with animal models. Notwithstanding the acknowledged study limitations (lack of individual exposure markers, short latency, and small population size for certain cancer types), results of previous experimental and epidemiological studies, along with mechanistic knowledge on dioxin toxicity, support the hypotheses that the observed excesses might be associated with dioxin exposure. The mortality and cancer incidence follow-up of the Seveso cohort are continuing.

Original languageEnglish
Pages (from-to)127-138
Number of pages12
JournalIndustrial Health
Volume41
Issue number3
Publication statusPublished - Jul 2003

Fingerprint

Dioxins
morbidity
dioxin
Accidents
accident
Morbidity
mortality
cancer
Mortality
Population
Neoplasms
Chloracne
Digestive System Neoplasms
Digestive system
Respiratory system
Pleura
Incidence
Sex Ratio
Biliary Tract
Disasters

Keywords

  • Cancer
  • Dioxins
  • Environmental Health
  • Epidemiology
  • Morbidity
  • Mortality

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Short- and long-term morbidity and mortality in the population exposed to dioxin after the "Seveso accident". / Pesatori, Angela Cecilia; Consonni, Dario; Bachetti, Silvia; Zocchetti, Carlo; Bonzini, Matteo; Baccarelli, Andrea; Bertazzi, Pier Alberto.

In: Industrial Health, Vol. 41, No. 3, 07.2003, p. 127-138.

Research output: Contribution to journalArticle

@article{9739a9a2b6f845f993c4e38b11714059,
title = "Short- and long-term morbidity and mortality in the population exposed to dioxin after the {"}Seveso accident{"}",
abstract = "The early effects of 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) exposure in the population involved in the Seveso, Italy, incident in 1976, have been examined in numerous studies. Chloracne was the only effect linked with sufficient certainty to dioxin exposure. The possible long-term consequences were investigated with mortality and cancer incidence studies. Mortality and morbidity findings during the 20-year period following the accident showed increased risk from lymphoemopoietic neoplasm, digestive system cancer (rectum in males, and biliary tract among females, in particular) and respiratory system cancer (lung, among males). In the incidence analyses, also thyroid gland and pleura cancer appeared suggestively increased. Soft tissue sarcomas showed an increase in the largest, yet least exposed, exposure sub-cohort. Several hypotheses associating non-cancer effects with dioxin exposure were corroborated by findings in the Seveso population: this was the case with cardiovascular effects (possibly linked to both chemical exposure and stressful disaster experience), endocrine effects (diabetes among females) and reproductive effects: exposure of men to TCDD was linked to a lowered male/female sex ratio in their offspring. The results of many Seveso studies point to possible gender effects, in accordance with animal models. Notwithstanding the acknowledged study limitations (lack of individual exposure markers, short latency, and small population size for certain cancer types), results of previous experimental and epidemiological studies, along with mechanistic knowledge on dioxin toxicity, support the hypotheses that the observed excesses might be associated with dioxin exposure. The mortality and cancer incidence follow-up of the Seveso cohort are continuing.",
keywords = "Cancer, Dioxins, Environmental Health, Epidemiology, Morbidity, Mortality",
author = "Pesatori, {Angela Cecilia} and Dario Consonni and Silvia Bachetti and Carlo Zocchetti and Matteo Bonzini and Andrea Baccarelli and Bertazzi, {Pier Alberto}",
year = "2003",
month = "7",
language = "English",
volume = "41",
pages = "127--138",
journal = "Industrial Health",
issn = "0019-8366",
publisher = "National Institute of Industrial Health",
number = "3",

}

TY - JOUR

T1 - Short- and long-term morbidity and mortality in the population exposed to dioxin after the "Seveso accident"

AU - Pesatori, Angela Cecilia

AU - Consonni, Dario

AU - Bachetti, Silvia

AU - Zocchetti, Carlo

AU - Bonzini, Matteo

AU - Baccarelli, Andrea

AU - Bertazzi, Pier Alberto

PY - 2003/7

Y1 - 2003/7

N2 - The early effects of 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) exposure in the population involved in the Seveso, Italy, incident in 1976, have been examined in numerous studies. Chloracne was the only effect linked with sufficient certainty to dioxin exposure. The possible long-term consequences were investigated with mortality and cancer incidence studies. Mortality and morbidity findings during the 20-year period following the accident showed increased risk from lymphoemopoietic neoplasm, digestive system cancer (rectum in males, and biliary tract among females, in particular) and respiratory system cancer (lung, among males). In the incidence analyses, also thyroid gland and pleura cancer appeared suggestively increased. Soft tissue sarcomas showed an increase in the largest, yet least exposed, exposure sub-cohort. Several hypotheses associating non-cancer effects with dioxin exposure were corroborated by findings in the Seveso population: this was the case with cardiovascular effects (possibly linked to both chemical exposure and stressful disaster experience), endocrine effects (diabetes among females) and reproductive effects: exposure of men to TCDD was linked to a lowered male/female sex ratio in their offspring. The results of many Seveso studies point to possible gender effects, in accordance with animal models. Notwithstanding the acknowledged study limitations (lack of individual exposure markers, short latency, and small population size for certain cancer types), results of previous experimental and epidemiological studies, along with mechanistic knowledge on dioxin toxicity, support the hypotheses that the observed excesses might be associated with dioxin exposure. The mortality and cancer incidence follow-up of the Seveso cohort are continuing.

AB - The early effects of 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) exposure in the population involved in the Seveso, Italy, incident in 1976, have been examined in numerous studies. Chloracne was the only effect linked with sufficient certainty to dioxin exposure. The possible long-term consequences were investigated with mortality and cancer incidence studies. Mortality and morbidity findings during the 20-year period following the accident showed increased risk from lymphoemopoietic neoplasm, digestive system cancer (rectum in males, and biliary tract among females, in particular) and respiratory system cancer (lung, among males). In the incidence analyses, also thyroid gland and pleura cancer appeared suggestively increased. Soft tissue sarcomas showed an increase in the largest, yet least exposed, exposure sub-cohort. Several hypotheses associating non-cancer effects with dioxin exposure were corroborated by findings in the Seveso population: this was the case with cardiovascular effects (possibly linked to both chemical exposure and stressful disaster experience), endocrine effects (diabetes among females) and reproductive effects: exposure of men to TCDD was linked to a lowered male/female sex ratio in their offspring. The results of many Seveso studies point to possible gender effects, in accordance with animal models. Notwithstanding the acknowledged study limitations (lack of individual exposure markers, short latency, and small population size for certain cancer types), results of previous experimental and epidemiological studies, along with mechanistic knowledge on dioxin toxicity, support the hypotheses that the observed excesses might be associated with dioxin exposure. The mortality and cancer incidence follow-up of the Seveso cohort are continuing.

KW - Cancer

KW - Dioxins

KW - Environmental Health

KW - Epidemiology

KW - Morbidity

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=0043172481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0043172481&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 127

EP - 138

JO - Industrial Health

JF - Industrial Health

SN - 0019-8366

IS - 3

ER -