TY - JOUR
T1 - Short Communication
T2 - Immune Activation is Present in HIV-1-Exposed Seronegative Individuals and is Independent of Microbial Translocation
AU - Saulle, Irma
AU - Biasin, Mara
AU - Gnudi, Federica
AU - Rainone, Veronica
AU - Ibba, Salomè Valentina
AU - Caputo, Sergio Lo
AU - Mazzotta, Francesco
AU - Trabattoni, Daria
AU - Clerici, Mario
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Analyses of immune activation in HIV-exposed seronegative individuals (HESN) yielded discrepant results. To clarify this issue we performed an extensive investigation of immune parameters in HESN and, in particular, we analyzed in these individuals the possible presence of microbial translocation, the most widely accepted reason driving immune activation in HIV-infected patients. Results showed that immune activation, a skewing of T lymphocyte maturation, and increased responsiveness to lipopolysaccharide (LPS) characterize the HESN phenotype; this is not driven by alterations of the gastrointestinal barrier and microbial translocation. The activation state seen in HESN may influence the induction of stronger adaptive antiviral immune responses and may represent a virus exposure-induced innate immune protective phenotype against HIV.
AB - Analyses of immune activation in HIV-exposed seronegative individuals (HESN) yielded discrepant results. To clarify this issue we performed an extensive investigation of immune parameters in HESN and, in particular, we analyzed in these individuals the possible presence of microbial translocation, the most widely accepted reason driving immune activation in HIV-infected patients. Results showed that immune activation, a skewing of T lymphocyte maturation, and increased responsiveness to lipopolysaccharide (LPS) characterize the HESN phenotype; this is not driven by alterations of the gastrointestinal barrier and microbial translocation. The activation state seen in HESN may influence the induction of stronger adaptive antiviral immune responses and may represent a virus exposure-induced innate immune protective phenotype against HIV.
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U2 - 10.1089/aid.2015.0019
DO - 10.1089/aid.2015.0019
M3 - Article
AN - SCOPUS:84958964972
VL - 32
SP - 129
EP - 133
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 2
ER -