TY - JOUR
T1 - Short contact therapy with tazarotene in psoriasis vulgaris
AU - Veraldi, Stefano
AU - Caputo, Ruggero
AU - Pacifico, Alessia
AU - Peris, Ketty
AU - Soda, Rosario
AU - Chimenti, Sergio
PY - 2006/3
Y1 - 2006/3
N2 - Background: We present the results of a multicentre, not controlled, clinical study on the tolerability and efficacy of tazarotene gel, used as short contact therapy (SCT), in psoriasis vulgaris. Objective: To evaluate whether irritant contact dermatitis caused by tazarotene was less frequent and/or less severe with SCT than with traditional therapy, and whether SCT with tazarotene was as effective as traditional therapy. Methods: Forty-three patients with plaque psoriasis were treated by SCT with 0.1% tazarotene gel (once daily application for 20 min, followed by washing with water). Treatment duration was 45 days. Results: Irritant contact dermatitis caused by tazarotene used as SCT was much less frequent and severe than traditional treatment with the same drug. SCT with tazarotene was effective in the treatment of plaque psoriasis. Conclusion: Tazarotene, used as SCT, was better tolerated than the same drug used as traditional treatment. Furthermore, SCT appeared to be as effective as traditional therapy with the same drug.
AB - Background: We present the results of a multicentre, not controlled, clinical study on the tolerability and efficacy of tazarotene gel, used as short contact therapy (SCT), in psoriasis vulgaris. Objective: To evaluate whether irritant contact dermatitis caused by tazarotene was less frequent and/or less severe with SCT than with traditional therapy, and whether SCT with tazarotene was as effective as traditional therapy. Methods: Forty-three patients with plaque psoriasis were treated by SCT with 0.1% tazarotene gel (once daily application for 20 min, followed by washing with water). Treatment duration was 45 days. Results: Irritant contact dermatitis caused by tazarotene used as SCT was much less frequent and severe than traditional treatment with the same drug. SCT with tazarotene was effective in the treatment of plaque psoriasis. Conclusion: Tazarotene, used as SCT, was better tolerated than the same drug used as traditional treatment. Furthermore, SCT appeared to be as effective as traditional therapy with the same drug.
KW - Contact dermatitis, irritant
KW - Contact therapy, short
KW - Psoriasis vulgaris
KW - Tazarotene
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U2 - 10.1159/000091250
DO - 10.1159/000091250
M3 - Article
C2 - 16549919
AN - SCOPUS:33645214422
VL - 212
SP - 235
EP - 237
JO - Dermatology
JF - Dermatology
SN - 1018-8665
IS - 3
ER -