Abstract
Background: The incidence of glioblastoma (GBM) in the elderly population is currently increasing, with a peak seen between 65 and 84 years. The optimal treatment in terms of both efficacy and quality of life still remains a relevant and debated issue today. The purpose of our study was to evaluate the feasibility of short-course hypofractionated accelerated radiotherapy (HART) in GBM patients aged over 70 years and with a good Karnofsky performance score (KPS). Methods: A review of medical records at the "Istituto Neurologico C. Besta" was undertaken; patients aged ≥ 70 years who had undergone adjuvant HART for GBM between January 2000 and January 2004 were included in the study. HART was administered to a total dose of 45 Gy, 2.5 Gy/fraction, in three daily fractions for three consecutive days/cycle fractions each, delivered in two cycles (split 15 days). Results: A total of 33 patients were evaluable for the current analysis. Median follow-up was 10 months. According to CTCAE (version 3.0) criteria, none of the patients developed radiation-induced neurological status deterioration or necrosis. KPS evaluation after HART was found to be stable in 73 % of patients, improved in 24 %, and worse in 3 %. The median overall survival time of the entire study population was 8 months (range 2-24). Conclusions: Our findings suggest that a hypofractionated accelerated schedule can be a safe and effective option in the treatment of GBM in the elderly.
| Original language | English |
|---|---|
| Pages (from-to) | 456-461 |
| Number of pages | 6 |
| Journal | Strahlentherapie und Onkologie |
| Volume | 189 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2013 |
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Keywords
- Elderly
- Glioblastoma
- Hypofractionated
- Radiation therapy
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Oncology
Cite this
Short-course radiotherapy in elderly patients with glioblastoma : Feasibility and efficacy of results from a single centre. / Fariselli, L.; Pinzi, V.; Milanesi, I.; Silvani, A.; Marchetti, M.; Farinotti, M.; Salmaggi, A.
In: Strahlentherapie und Onkologie, Vol. 189, No. 6, 06.2013, p. 456-461.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Short-course radiotherapy in elderly patients with glioblastoma
T2 - Feasibility and efficacy of results from a single centre
AU - Fariselli, L.
AU - Pinzi, V.
AU - Milanesi, I.
AU - Silvani, A.
AU - Marchetti, M.
AU - Farinotti, M.
AU - Salmaggi, A.
PY - 2013/6
Y1 - 2013/6
N2 - Background: The incidence of glioblastoma (GBM) in the elderly population is currently increasing, with a peak seen between 65 and 84 years. The optimal treatment in terms of both efficacy and quality of life still remains a relevant and debated issue today. The purpose of our study was to evaluate the feasibility of short-course hypofractionated accelerated radiotherapy (HART) in GBM patients aged over 70 years and with a good Karnofsky performance score (KPS). Methods: A review of medical records at the "Istituto Neurologico C. Besta" was undertaken; patients aged ≥ 70 years who had undergone adjuvant HART for GBM between January 2000 and January 2004 were included in the study. HART was administered to a total dose of 45 Gy, 2.5 Gy/fraction, in three daily fractions for three consecutive days/cycle fractions each, delivered in two cycles (split 15 days). Results: A total of 33 patients were evaluable for the current analysis. Median follow-up was 10 months. According to CTCAE (version 3.0) criteria, none of the patients developed radiation-induced neurological status deterioration or necrosis. KPS evaluation after HART was found to be stable in 73 % of patients, improved in 24 %, and worse in 3 %. The median overall survival time of the entire study population was 8 months (range 2-24). Conclusions: Our findings suggest that a hypofractionated accelerated schedule can be a safe and effective option in the treatment of GBM in the elderly.
AB - Background: The incidence of glioblastoma (GBM) in the elderly population is currently increasing, with a peak seen between 65 and 84 years. The optimal treatment in terms of both efficacy and quality of life still remains a relevant and debated issue today. The purpose of our study was to evaluate the feasibility of short-course hypofractionated accelerated radiotherapy (HART) in GBM patients aged over 70 years and with a good Karnofsky performance score (KPS). Methods: A review of medical records at the "Istituto Neurologico C. Besta" was undertaken; patients aged ≥ 70 years who had undergone adjuvant HART for GBM between January 2000 and January 2004 were included in the study. HART was administered to a total dose of 45 Gy, 2.5 Gy/fraction, in three daily fractions for three consecutive days/cycle fractions each, delivered in two cycles (split 15 days). Results: A total of 33 patients were evaluable for the current analysis. Median follow-up was 10 months. According to CTCAE (version 3.0) criteria, none of the patients developed radiation-induced neurological status deterioration or necrosis. KPS evaluation after HART was found to be stable in 73 % of patients, improved in 24 %, and worse in 3 %. The median overall survival time of the entire study population was 8 months (range 2-24). Conclusions: Our findings suggest that a hypofractionated accelerated schedule can be a safe and effective option in the treatment of GBM in the elderly.
KW - Elderly
KW - Glioblastoma
KW - Hypofractionated
KW - Radiation therapy
UR - http://www.scopus.com/inward/record.url?scp=84878300300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878300300&partnerID=8YFLogxK
U2 - 10.1007/s00066-013-0346-x
DO - 10.1007/s00066-013-0346-x
M3 - Article
C2 - 23625362
AN - SCOPUS:84878300300
VL - 189
SP - 456
EP - 461
JO - Strahlentherapie und Onkologie
JF - Strahlentherapie und Onkologie
SN - 0179-7158
IS - 6
ER -