Short-Form Charlson Comorbidity Index for Assessment of Perioperative Mortality After Radical Cystectomy

P Dell'Oglio, Z Tian, SR Leyh-Bannurah, V Trudeau, A Larcher, M Moschini, E Di Trapani, U Capitanio, A Briganti, F Montorsi, F Saad, PI Karakiewicz

Research output: Contribution to journalArticlepeer-review


Background: The Deyo adaptation of the Charlson comorbidity index (DaCCI), which relies on 17 comorbid condition groupings, represents one of the most frequently used baseline comorbidity assessment tools in retrospective database studies. However, this index is not specific for patients with bladder cancer (BCa) treated with radical cystectomy (RC). The goal of this study was to develop a short-form of the original DaCCI (DaCCI-SF) that may specifically predict 90-day mortality after RC, with equal or better accuracy. Patients and Methods: Between 2000 and 2009, we identified 7,076 patients in the SEER-Medicare database with stage T1 through T4 nonmetastatic BCa treated with RC. We randomly divided the population into development (n=6,076) and validation (n=1,000) cohorts. Within the development cohort, logistic regression models tested the ability to predict 90-day mortality with various iterations of the DaCCI-SF, wherein 75 years), stage (organ-confined vs non-organ-confined), type of diversion (ileal-conduit vs non-ileal-conduit), and treatment period. Conclusions: DaCCI-SF relies on 17.6% of the original comorbid condition groupings and provides higher accuracy for predicting 90-day mortality after RC compared with the original DaCCI, especially in most contemporary patients. Copyright © 2017 by the National Comprehensive Cancer Network.
Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalJournal of the National Comprehensive Cancer Network : JNCCN
Issue number3
Publication statusPublished - 2017


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