TY - JOUR
T1 - Short-lived immunization site inflammation in self-limited active experimental allergic encephalomyelitis
AU - Di Rosa, Francesca
AU - Serafini, Barbara
AU - Scognamiglio, Paola
AU - Di Virgilio, Antonio
AU - Finocchi, Luigi
AU - Aloisi, Francesca
AU - Barnaba, Vincenzo
PY - 2000
Y1 - 2000
N2 - To understand the mechanisms underlying spontaneous remission of proteolipid protein (PLP) 139-151 peptide-induced experimental allergic encephalomyelitis (EAE), an acute autoimmune disease of SJL mice resembling human multiple sclerosis, we examined both the effector response site in the central nervous system (CNS) and the immunization site at different phases of the disease. In the CNS, the frequency of PLP 139-151 peptide-specific IFN-γ-producing T cells as well as the amount of infiltrating CD4+ and CD11b+ cells decreased with recovery. However, IL-4-producing cells were always rare and cyclooxygenase-2+ cells were numerous only at disease peak in the CNS, suggesting that T(h)2 cytokines and prostaglandins did not determine remission of EAE. By looking at the s.c. site of PLP 139-151 peptide plus adjuvant injection, we found that, although the inflammatory infiltrate was abundant, CD11b+ cells started to decrease already during disease acute phase and DEC-205+ cells were numerous only at early time points. We propose that immunization site inflammation is short-lived in PLP 139-151 peptide-induced EAE, and this leads to a temporary autoreactive T cell stimulation and to a self-limited disease.
AB - To understand the mechanisms underlying spontaneous remission of proteolipid protein (PLP) 139-151 peptide-induced experimental allergic encephalomyelitis (EAE), an acute autoimmune disease of SJL mice resembling human multiple sclerosis, we examined both the effector response site in the central nervous system (CNS) and the immunization site at different phases of the disease. In the CNS, the frequency of PLP 139-151 peptide-specific IFN-γ-producing T cells as well as the amount of infiltrating CD4+ and CD11b+ cells decreased with recovery. However, IL-4-producing cells were always rare and cyclooxygenase-2+ cells were numerous only at disease peak in the CNS, suggesting that T(h)2 cytokines and prostaglandins did not determine remission of EAE. By looking at the s.c. site of PLP 139-151 peptide plus adjuvant injection, we found that, although the inflammatory infiltrate was abundant, CD11b+ cells started to decrease already during disease acute phase and DEC-205+ cells were numerous only at early time points. We propose that immunization site inflammation is short-lived in PLP 139-151 peptide-induced EAE, and this leads to a temporary autoreactive T cell stimulation and to a self-limited disease.
KW - Adjuvant
KW - Autoimmunity
KW - Immunization
KW - Inflammation
KW - T cell cytokines
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UR - http://www.scopus.com/inward/citedby.url?scp=0034018707&partnerID=8YFLogxK
M3 - Article
C2 - 10784617
AN - SCOPUS:0034018707
VL - 12
SP - 711
EP - 719
JO - International Immunology
JF - International Immunology
SN - 0953-8178
IS - 5
ER -