Short sleep duration and cardiometabolic risk: from pathophysiology to clinical evidence

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10 Citations (Scopus)

Abstract

Short sleep duration has a substantial influence on the overall health of an individual. Short sleep time can be a consequence of lifestyle habits, environmental factors, or the presence of a sleep disorder, such as insomnia or sleep-disordered breathing. Short sleep time is associated with increased morbidity and mortality, mainly from cardiovascular disorders (including coronary artery disease, arrhythmias, and hypertension). Several biological mechanisms have been proposed as a possible link between short sleep duration and these diseases, such as involvement of the autonomic nervous system, endothelial function, metabolic regulation, inflammation, and the coagulation system. In this Review, we provide an overview on the effects of short sleep duration on cardiovascular health and diseases and discuss the main pathophysiological mechanisms involved, taking into account both experimental data and clinical evidence.

Original languageEnglish
Pages (from-to)213-224
JournalNature Reviews Cardiology
Volume16
Issue number4
DOIs
Publication statusPublished - 2019

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Sleep
Autonomic Nervous System
Sleep Apnea Syndromes
Health
Sleep Initiation and Maintenance Disorders
Habits
Life Style
Cardiac Arrhythmias
Coronary Artery Disease
Cardiovascular Diseases
Hypertension
Inflammation
Morbidity
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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AU - Tobaldini, Eleonora

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AU - Costantino, Giorgio

AU - Nobili, Lino

AU - Montano, Nicola

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