Short stature and celiac disease: A relationship to consider even in patients with no gastrointestinal tract symptoms

E. Cacciari, S. Salardi, R. Lazzari, A. Cicognani, A. Collina, P. Pirazzoli, P. Tassoni, G. Biasco, G. R. Corazza, A. Cassio

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

To determine the incidence of celiac disease in a group of nonselected children with short stature, duodenal biopsy was performed in 60 unselected children with short stature (below third centile) and absence of gastrointestinal tract symptoms. Examination revealed probable celiac disease in five children (8.3%). Analysis of the results of other tests that might possibly be considered as alternatives to biopsy (e.g., xylose test, antireticulin antibodies, gastrointestinal tract symptoms in the first two years of life, bone age, serum iron, iron load, triglyceride load) led us to conclude that no test or clinical measurement could have allowed us 100% certainty in making the correct diagnosis. None of the children with celiac disease had growth hormone deficiency. We conclude that asymptomatic celiac disease represents a cause of short stature that cannot be ignored, and that only by intestinal biopsy can all such patients be identified.

Original languageEnglish
Pages (from-to)708-711
Number of pages4
JournalJournal of Pediatrics
Volume103
Issue number5
DOIs
Publication statusPublished - 1983

Fingerprint

Celiac Disease
Gastrointestinal Tract
Biopsy
Iron
Asymptomatic Diseases
Xylose
Growth Hormone
Triglycerides
Bone and Bones
Antibodies
Incidence
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cacciari, E., Salardi, S., Lazzari, R., Cicognani, A., Collina, A., Pirazzoli, P., ... Cassio, A. (1983). Short stature and celiac disease: A relationship to consider even in patients with no gastrointestinal tract symptoms. Journal of Pediatrics, 103(5), 708-711. https://doi.org/10.1016/S0022-3476(83)80462-4

Short stature and celiac disease : A relationship to consider even in patients with no gastrointestinal tract symptoms. / Cacciari, E.; Salardi, S.; Lazzari, R.; Cicognani, A.; Collina, A.; Pirazzoli, P.; Tassoni, P.; Biasco, G.; Corazza, G. R.; Cassio, A.

In: Journal of Pediatrics, Vol. 103, No. 5, 1983, p. 708-711.

Research output: Contribution to journalArticle

Cacciari, E, Salardi, S, Lazzari, R, Cicognani, A, Collina, A, Pirazzoli, P, Tassoni, P, Biasco, G, Corazza, GR & Cassio, A 1983, 'Short stature and celiac disease: A relationship to consider even in patients with no gastrointestinal tract symptoms', Journal of Pediatrics, vol. 103, no. 5, pp. 708-711. https://doi.org/10.1016/S0022-3476(83)80462-4
Cacciari, E. ; Salardi, S. ; Lazzari, R. ; Cicognani, A. ; Collina, A. ; Pirazzoli, P. ; Tassoni, P. ; Biasco, G. ; Corazza, G. R. ; Cassio, A. / Short stature and celiac disease : A relationship to consider even in patients with no gastrointestinal tract symptoms. In: Journal of Pediatrics. 1983 ; Vol. 103, No. 5. pp. 708-711.
@article{060ab37bab4040dbae8a8f65363adefd,
title = "Short stature and celiac disease: A relationship to consider even in patients with no gastrointestinal tract symptoms",
abstract = "To determine the incidence of celiac disease in a group of nonselected children with short stature, duodenal biopsy was performed in 60 unselected children with short stature (below third centile) and absence of gastrointestinal tract symptoms. Examination revealed probable celiac disease in five children (8.3{\%}). Analysis of the results of other tests that might possibly be considered as alternatives to biopsy (e.g., xylose test, antireticulin antibodies, gastrointestinal tract symptoms in the first two years of life, bone age, serum iron, iron load, triglyceride load) led us to conclude that no test or clinical measurement could have allowed us 100{\%} certainty in making the correct diagnosis. None of the children with celiac disease had growth hormone deficiency. We conclude that asymptomatic celiac disease represents a cause of short stature that cannot be ignored, and that only by intestinal biopsy can all such patients be identified.",
author = "E. Cacciari and S. Salardi and R. Lazzari and A. Cicognani and A. Collina and P. Pirazzoli and P. Tassoni and G. Biasco and Corazza, {G. R.} and A. Cassio",
year = "1983",
doi = "10.1016/S0022-3476(83)80462-4",
language = "English",
volume = "103",
pages = "708--711",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Short stature and celiac disease

T2 - A relationship to consider even in patients with no gastrointestinal tract symptoms

AU - Cacciari, E.

AU - Salardi, S.

AU - Lazzari, R.

AU - Cicognani, A.

AU - Collina, A.

AU - Pirazzoli, P.

AU - Tassoni, P.

AU - Biasco, G.

AU - Corazza, G. R.

AU - Cassio, A.

PY - 1983

Y1 - 1983

N2 - To determine the incidence of celiac disease in a group of nonselected children with short stature, duodenal biopsy was performed in 60 unselected children with short stature (below third centile) and absence of gastrointestinal tract symptoms. Examination revealed probable celiac disease in five children (8.3%). Analysis of the results of other tests that might possibly be considered as alternatives to biopsy (e.g., xylose test, antireticulin antibodies, gastrointestinal tract symptoms in the first two years of life, bone age, serum iron, iron load, triglyceride load) led us to conclude that no test or clinical measurement could have allowed us 100% certainty in making the correct diagnosis. None of the children with celiac disease had growth hormone deficiency. We conclude that asymptomatic celiac disease represents a cause of short stature that cannot be ignored, and that only by intestinal biopsy can all such patients be identified.

AB - To determine the incidence of celiac disease in a group of nonselected children with short stature, duodenal biopsy was performed in 60 unselected children with short stature (below third centile) and absence of gastrointestinal tract symptoms. Examination revealed probable celiac disease in five children (8.3%). Analysis of the results of other tests that might possibly be considered as alternatives to biopsy (e.g., xylose test, antireticulin antibodies, gastrointestinal tract symptoms in the first two years of life, bone age, serum iron, iron load, triglyceride load) led us to conclude that no test or clinical measurement could have allowed us 100% certainty in making the correct diagnosis. None of the children with celiac disease had growth hormone deficiency. We conclude that asymptomatic celiac disease represents a cause of short stature that cannot be ignored, and that only by intestinal biopsy can all such patients be identified.

UR - http://www.scopus.com/inward/record.url?scp=0021084416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021084416&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(83)80462-4

DO - 10.1016/S0022-3476(83)80462-4

M3 - Article

C2 - 6631596

AN - SCOPUS:0021084416

VL - 103

SP - 708

EP - 711

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 5

ER -