Experimental studies have indicated that the renin-angiotensin system may regulate plasminogen activation and fibrinolysis and that angiotensin- converting enzyme (ACE) inhibitors are able to reduce the rate of myocardial infarction, possibly by interfering with haemostatic system. However, no data are available on the effect of ACE inhibition on haemostasis in healthy subjects. The aim of this study was to evaluate the effects of short-term ACE inhibition on haemostasis, both in baseline conditions and after a standardized exercise stress test in healthy subjects. Ten male control subjects (age 25-40 years) were enrolled in a randomized, double blind, placebo-controlled cross-over study. They assumed enalapril 20 mg or placebo once daily for 7 days, then, after a 15-day washout period, treatments were crossed. Treadmill stress test was performed before and after each 7-day treatment period. Blood sampling for fibrinolysis and coagulation studies were performed before exercise and after maximal exercise. The exercise- induced decrease in ELT and plasminogen activator inhibitor-1 and the increase in tissue plasminogen activator were more marked after enalapril than after placebo. No differences were seen in signs of exercise-induced clotting activation. These data indicate that a short-term treatment with enalapril in healthy subjects is able to affect fibrinolysis response to a physiological stimulation such as physical effort. These results may be of help in the study of complex relationships among ACE inhibition, haemostasis and reduction in myocardial infarction.
|Number of pages||6|
|Journal||Fibrinolysis and Proteolysis|
|Publication status||Published - 1997|
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