Short-term administration of tibolone plus GnRH analog before laparoscopic myomectomy

Stefano Palomba, Michele Morelli, Roberto Noia, Marco Santagata, Anna Oliverio, Teresa Sena, Fulvio Zullo, Pasquale Mastrantonio

Research output: Contribution to journalArticlepeer-review


Study Objective. To evaluate whether tibolone modifies the effectiveness of gonadotropin-releasing hormone (GnRH) analog administered before laparoscopic myomectomy. Design. Prospective, randomized, open, placebo-controlled clinical trial (Canadian Task Force classification I). Setting. University-affiliated hospital. Patients. Sixty-six women with symptomatic leiomyomas. Interventions. Patients received 2 months of treatment with GnRH analog and iron plus tibolone (group A) or placebo (group B); group C received only iron. Laparoscopic myomectomy was performed after medical treatment. Measurements and Main Results. Uterine volume, number and volume of leiomyomas, echogenicity and volume of the largest leiomyomas, hematologic values, and myoma-related symptoms were evaluated at baseline, 1 week before, and 1 week after surgery. We observed significant (p

Original languageEnglish
Pages (from-to)170-174
Number of pages5
JournalAmerican Association of Gynecologic Laparoscopists
Issue number2
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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