TY - JOUR
T1 - Short-term and long-term plasticity at corticostriatal synapses
T2 - Implications for learning and memory
AU - Di Filippo, Massimiliano
AU - Picconi, Barbara
AU - Tantucci, Michela
AU - Ghiglieri, Veronica
AU - Bagetta, Vincenza
AU - Sgobio, Carmelo
AU - Tozzi, Alessandro
AU - Parnetti, Lucilla
AU - Calabresi, Paolo
PY - 2009/4/12
Y1 - 2009/4/12
N2 - The striatum is the major division of the basal ganglia, representing the input station of the circuit and arguably the principal site within the basal ganglia where information processing occurs. Striatal activity is critically involved in motor control and learning. Many parts of the striatum are involved in reward processing and in various forms of learning and memory, such as reward-association learning. Moreover, the striatum appears to be a brain center for habit formation and is likely to be involved in advanced stages of addiction. The critical role played by the striatum in learning and cognitive processes is thought to be based on changes in neuronal activity when specific behavioral tasks are being learned. Accordingly, excitatory corticostriatal synapses onto both striatal projecting spiny neurons and interneurons are able to undergo the main forms of synaptic plasticity, including long-term potentiation, long-term depression, short-term forms of intrinsic plasticity and spike timing-dependent plasticity. These specific forms of neuroplasticity allow the short-term and long-term selection and differential amplification of cortical neural signals modulating the processes of motor and behavioral selection within the basal ganglia neural circuit.
AB - The striatum is the major division of the basal ganglia, representing the input station of the circuit and arguably the principal site within the basal ganglia where information processing occurs. Striatal activity is critically involved in motor control and learning. Many parts of the striatum are involved in reward processing and in various forms of learning and memory, such as reward-association learning. Moreover, the striatum appears to be a brain center for habit formation and is likely to be involved in advanced stages of addiction. The critical role played by the striatum in learning and cognitive processes is thought to be based on changes in neuronal activity when specific behavioral tasks are being learned. Accordingly, excitatory corticostriatal synapses onto both striatal projecting spiny neurons and interneurons are able to undergo the main forms of synaptic plasticity, including long-term potentiation, long-term depression, short-term forms of intrinsic plasticity and spike timing-dependent plasticity. These specific forms of neuroplasticity allow the short-term and long-term selection and differential amplification of cortical neural signals modulating the processes of motor and behavioral selection within the basal ganglia neural circuit.
KW - Basal ganglia
KW - Long-term depression
KW - Long-term potentiation
KW - Memory
KW - Striatum
KW - Synaptic plasticity
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U2 - 10.1016/j.bbr.2008.09.025
DO - 10.1016/j.bbr.2008.09.025
M3 - Article
C2 - 18948145
AN - SCOPUS:61349162306
VL - 199
SP - 108
EP - 118
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 1
ER -