Short-term anti-ischemic effect of 17β-estradiol in postmenopausal women with coronary artery disease

Giuseppe M C Rosano; Adriano Mendes Caixeta; Sergio Chierchia; Siguemituzo Arie; Miguel Lopez-Hidalgo; Wagner I. Pereira; Filippo Leonardo; Carolyn M. Webb; Fulvio Pileggi; Peter Collins

Short-term anti-ischemic effect of 17β-estradiol in postmenopausal women with coronary artery disease

Giuseppe M C Rosano, Adriano Mendes Caixeta, Sergio Chierchia, Siguemituzo Arie, Miguel Lopez-Hidalgo, Wagner I. Pereira, Filippo Leonardo, Carolyn M. Webb, Fulvio Pileggi, Peter Collins

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Short-term administration of 17β-estradiol improves effort- induced myocardial ischemia in female patients with coronary artery disease. 17β-Estradiol also has direct and indirect coronary vascular smooth muscle relaxing properties. The aim of the present study was to evaluate the effect of short-term administration of 17β-estradiol on pacing-induced myocardial ischemia by means of continuous monitoring of coronary sinus pH in 16 postmenopausal female patients with coronary artery disease. Methods and Results: Patients underwent incremental atrial pacing starting at a rate of 100 bpm and increments of 20 bpm every 2 minutes up to 160 bpm before and 20 minutes after either 17β-estradiol (1 mg sublingual, 9 patients) or placebo (sublingual, 7 patients). The time to the onset of myocardial ischemia during pacing was significantly increased by 17β-estradiol (mean±SD, 254±36 versus 298±23 seconds; P

Original language	English
Pages (from-to)	2837-2841
Number of pages	5
Journal	Circulation
Volume	96
Issue number	9
Publication status	Published - Nov 4 1997

Keywords

Coronary disease
Estrogen
Hormones
Ischemia
Women

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Cite this

Short-term anti-ischemic effect of 17β-estradiol in postmenopausal women with coronary artery disease. / Rosano, Giuseppe M C; Caixeta, Adriano Mendes; Chierchia, Sergio; Arie, Siguemituzo; Lopez-Hidalgo, Miguel; Pereira, Wagner I.; Leonardo, Filippo; Webb, Carolyn M.; Pileggi, Fulvio; Collins, Peter.

In: Circulation, Vol. 96, No. 9, 04.11.1997, p. 2837-2841.

Research output: Contribution to journal › Article › peer-review

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title = "Short-term anti-ischemic effect of 17β-estradiol in postmenopausal women with coronary artery disease",

abstract = "Background: Short-term administration of 17β-estradiol improves effort- induced myocardial ischemia in female patients with coronary artery disease. 17β-Estradiol also has direct and indirect coronary vascular smooth muscle relaxing properties. The aim of the present study was to evaluate the effect of short-term administration of 17β-estradiol on pacing-induced myocardial ischemia by means of continuous monitoring of coronary sinus pH in 16 postmenopausal female patients with coronary artery disease. Methods and Results: Patients underwent incremental atrial pacing starting at a rate of 100 bpm and increments of 20 bpm every 2 minutes up to 160 bpm before and 20 minutes after either 17β-estradiol (1 mg sublingual, 9 patients) or placebo (sublingual, 7 patients). The time to the onset of myocardial ischemia during pacing was significantly increased by 17β-estradiol (mean±SD, 254±36 versus 298±23 seconds; P",

keywords = "Coronary disease, Estrogen, Hormones, Ischemia, Women",

author = "Rosano, {Giuseppe M C} and Caixeta, {Adriano Mendes} and Sergio Chierchia and Siguemituzo Arie and Miguel Lopez-Hidalgo and Pereira, {Wagner I.} and Filippo Leonardo and Webb, {Carolyn M.} and Fulvio Pileggi and Peter Collins",

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AU - Rosano, Giuseppe M C

AU - Caixeta, Adriano Mendes

AU - Chierchia, Sergio

AU - Arie, Siguemituzo

AU - Lopez-Hidalgo, Miguel

AU - Pereira, Wagner I.

AU - Leonardo, Filippo

AU - Webb, Carolyn M.

AU - Pileggi, Fulvio

AU - Collins, Peter

PY - 1997/11/4

Y1 - 1997/11/4

N2 - Background: Short-term administration of 17β-estradiol improves effort- induced myocardial ischemia in female patients with coronary artery disease. 17β-Estradiol also has direct and indirect coronary vascular smooth muscle relaxing properties. The aim of the present study was to evaluate the effect of short-term administration of 17β-estradiol on pacing-induced myocardial ischemia by means of continuous monitoring of coronary sinus pH in 16 postmenopausal female patients with coronary artery disease. Methods and Results: Patients underwent incremental atrial pacing starting at a rate of 100 bpm and increments of 20 bpm every 2 minutes up to 160 bpm before and 20 minutes after either 17β-estradiol (1 mg sublingual, 9 patients) or placebo (sublingual, 7 patients). The time to the onset of myocardial ischemia during pacing was significantly increased by 17β-estradiol (mean±SD, 254±36 versus 298±23 seconds; P

AB - Background: Short-term administration of 17β-estradiol improves effort- induced myocardial ischemia in female patients with coronary artery disease. 17β-Estradiol also has direct and indirect coronary vascular smooth muscle relaxing properties. The aim of the present study was to evaluate the effect of short-term administration of 17β-estradiol on pacing-induced myocardial ischemia by means of continuous monitoring of coronary sinus pH in 16 postmenopausal female patients with coronary artery disease. Methods and Results: Patients underwent incremental atrial pacing starting at a rate of 100 bpm and increments of 20 bpm every 2 minutes up to 160 bpm before and 20 minutes after either 17β-estradiol (1 mg sublingual, 9 patients) or placebo (sublingual, 7 patients). The time to the onset of myocardial ischemia during pacing was significantly increased by 17β-estradiol (mean±SD, 254±36 versus 298±23 seconds; P

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KW - Estrogen

KW - Hormones

KW - Ischemia

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Short-term anti-ischemic effect of 17β-estradiol in postmenopausal women with coronary artery disease

Abstract

Keywords

ASJC Scopus subject areas

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