Short-term anti-ischemic effect of 17β-estradiol in postmenopausal women with coronary artery disease

Giuseppe M C Rosano, Adriano Mendes Caixeta, Sergio Chierchia, Siguemituzo Arie, Miguel Lopez-Hidalgo, Wagner I. Pereira, Filippo Leonardo, Carolyn M. Webb, Fulvio Pileggi, Peter Collins

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Short-term administration of 17β-estradiol improves effort- induced myocardial ischemia in female patients with coronary artery disease. 17β-Estradiol also has direct and indirect coronary vascular smooth muscle relaxing properties. The aim of the present study was to evaluate the effect of short-term administration of 17β-estradiol on pacing-induced myocardial ischemia by means of continuous monitoring of coronary sinus pH in 16 postmenopausal female patients with coronary artery disease. Methods and Results: Patients underwent incremental atrial pacing starting at a rate of 100 bpm and increments of 20 bpm every 2 minutes up to 160 bpm before and 20 minutes after either 17β-estradiol (1 mg sublingual, 9 patients) or placebo (sublingual, 7 patients). The time to the onset of myocardial ischemia during pacing was significantly increased by 17β-estradiol (mean±SD, 254±36 versus 298±23 seconds; P

Original languageEnglish
Pages (from-to)2837-2841
Number of pages5
JournalCirculation
Volume96
Issue number9
Publication statusPublished - Nov 4 1997

Keywords

  • Coronary disease
  • Estrogen
  • Hormones
  • Ischemia
  • Women

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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