Abstract
Background: Short-term administration of 17β-estradiol improves effort- induced myocardial ischemia in female patients with coronary artery disease. 17β-Estradiol also has direct and indirect coronary vascular smooth muscle relaxing properties. The aim of the present study was to evaluate the effect of short-term administration of 17β-estradiol on pacing-induced myocardial ischemia by means of continuous monitoring of coronary sinus pH in 16 postmenopausal female patients with coronary artery disease. Methods and Results: Patients underwent incremental atrial pacing starting at a rate of 100 bpm and increments of 20 bpm every 2 minutes up to 160 bpm before and 20 minutes after either 17β-estradiol (1 mg sublingual, 9 patients) or placebo (sublingual, 7 patients). The time to the onset of myocardial ischemia during pacing was significantly increased by 17β-estradiol (mean±SD, 254±36 versus 298±23 seconds; P
Original language | English |
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Pages (from-to) | 2837-2841 |
Number of pages | 5 |
Journal | Circulation |
Volume | 96 |
Issue number | 9 |
Publication status | Published - Nov 4 1997 |
Keywords
- Coronary disease
- Estrogen
- Hormones
- Ischemia
- Women
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine