Short-term cardiac adaptation to severe haemodilution: An echocardiographic study in normal and hypertensive subjects

T. Bombardini, B. Borghi, F. Zaca, E. Picano, G. C. Caroli

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In order to avoid transfusion risks and optimize blood bank resources, in recent years many blood sparing techniques have been proposed, including severe haemodilution. The aim of this study is to assess the pattern of normal haemodynamic and cardiac adaptation to severe haemodilution in patients undergoing major orthopaedic surgery and refusing blood transfusions for religious reasons (the patients were Jehovah's Witnesses) Two-dimensionally guided M-mode echocardiograms were performed at baseline and 4 days after major orthopaedic surgery in 26 Jehovah's Witnesses (age 61 ± 11 years), with normal regional and global baseline left ventricular function and no valvular disease. Left ventricular (LV) volumes were estimated by using the Teichholz formula. From the latter, we calculated ejection fraction and stroke volume, cardiac output (stroke volume x heart rate), and total peripheral resistance estimated as mean arterial pressure by cuff sphygmomanometer x 80/cardiac output. On the basis of LV mass (ASE-cube corrected by Devereux), two groups were identified: non-hypertrophic (LV mass index <110g. m -2 in women and -2 in males) and hypertrophic. In the 19 patients without LV hypertrophy, haemoglobin decreased from 13.5 ± 1.6 (mean ± standard deviation) g. dl -1 (at baseline) to 8.7 ± 1.3 post-operation (P-5) (P-1, P-1, P

Original languageEnglish
Pages (from-to)637-640
Number of pages4
JournalEuropean Heart Journal
Volume15
Issue number5
Publication statusPublished - 1994

Fingerprint

Hemodilution
Jehovah's Witnesses
Cardiac Output
Stroke Volume
Orthopedics
Sphygmomanometers
Blood Banks
Left Ventricular Hypertrophy
Left Ventricular Function
Blood Transfusion
Vascular Resistance
Arterial Pressure
Hemoglobins
Heart Rate
Hemodynamics

Keywords

  • Echocardiography
  • Haemodilution
  • Hypertrophy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Short-term cardiac adaptation to severe haemodilution : An echocardiographic study in normal and hypertensive subjects. / Bombardini, T.; Borghi, B.; Zaca, F.; Picano, E.; Caroli, G. C.

In: European Heart Journal, Vol. 15, No. 5, 1994, p. 637-640.

Research output: Contribution to journalArticle

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