Short-term cortical synaptic depression/potentiation mechanisms in chronic migraine patients with or without medication overuse

Francesca Cortese, Francesco Pierelli, Flavia Pauri, Cherubino Di Lorenzo, Chiara Lepre, Giulia Malavolta, Chiara Merluzzo, Vincenzo Parisi, Mariano Serrao, Gianluca Coppola

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To study the effects of trains of repetitive transcranial magnetic stimulation (rTMS) over the motor cortex in patients with chronic migraine (CM) with or without medication overuse (MOH). Subjects and methods: Thirty-two patients (CM [n = 16]; MOH [n = 16]) and 16 healthy volunteers (HVs) underwent rTMS recording. Ten trains of 10 stimuli each (120% resting motor threshold) were applied over the left motor cortex at 1 Hz or 5 Hz in random order. The amplitude of motor evoked potential (MEP) was evaluated from electromyographic recording in the first dorsal interosseous muscle. The slope of the linear regression line for the 10 stimuli for each participant was calculated using normalized data. Results: rTMS-1 Hz had a normal depressive effect on MEP amplitude in all groups. rTMS-5 Hz depressed instead of potentiating MEP amplitudes in MOH patients, with a significantly different response from that in HVs and CM patients. The slope of the linear regression of MEP amplitudes was negatively correlated with pain intensity in CM patients, and with the duration of overuse headache in MOH patients. Conclusions: This different plastic behaviour suggests that MOH and CM, despite exhibiting a similar clinical phenotype, have different neurophysiological learning processes, probably related to different pathophysiological mechanisms of migraine chronification.

Original languageEnglish
JournalCephalalgia
DOIs
Publication statusE-pub ahead of print - Jan 1 2018

Fingerprint

Migraine Disorders
Motor Evoked Potentials
Transcranial Magnetic Stimulation
Motor Cortex
Linear Models
Healthy Volunteers
Plastics
Headache
Prescription Drug Overuse
Learning
Phenotype
Pain
Muscles

Keywords

  • chronic migraine
  • depression
  • potentiation
  • repetitive transcranial magnetic stimulation
  • Synaptic plasticity

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Short-term cortical synaptic depression/potentiation mechanisms in chronic migraine patients with or without medication overuse. / Cortese, Francesca; Pierelli, Francesco; Pauri, Flavia; Di Lorenzo, Cherubino; Lepre, Chiara; Malavolta, Giulia; Merluzzo, Chiara; Parisi, Vincenzo; Serrao, Mariano; Coppola, Gianluca.

In: Cephalalgia, 01.01.2018.

Research output: Contribution to journalArticle

Cortese, Francesca ; Pierelli, Francesco ; Pauri, Flavia ; Di Lorenzo, Cherubino ; Lepre, Chiara ; Malavolta, Giulia ; Merluzzo, Chiara ; Parisi, Vincenzo ; Serrao, Mariano ; Coppola, Gianluca. / Short-term cortical synaptic depression/potentiation mechanisms in chronic migraine patients with or without medication overuse. In: Cephalalgia. 2018.
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AU - Lepre, Chiara

AU - Malavolta, Giulia

AU - Merluzzo, Chiara

AU - Parisi, Vincenzo

AU - Serrao, Mariano

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N2 - Objective: To study the effects of trains of repetitive transcranial magnetic stimulation (rTMS) over the motor cortex in patients with chronic migraine (CM) with or without medication overuse (MOH). Subjects and methods: Thirty-two patients (CM [n = 16]; MOH [n = 16]) and 16 healthy volunteers (HVs) underwent rTMS recording. Ten trains of 10 stimuli each (120% resting motor threshold) were applied over the left motor cortex at 1 Hz or 5 Hz in random order. The amplitude of motor evoked potential (MEP) was evaluated from electromyographic recording in the first dorsal interosseous muscle. The slope of the linear regression line for the 10 stimuli for each participant was calculated using normalized data. Results: rTMS-1 Hz had a normal depressive effect on MEP amplitude in all groups. rTMS-5 Hz depressed instead of potentiating MEP amplitudes in MOH patients, with a significantly different response from that in HVs and CM patients. The slope of the linear regression of MEP amplitudes was negatively correlated with pain intensity in CM patients, and with the duration of overuse headache in MOH patients. Conclusions: This different plastic behaviour suggests that MOH and CM, despite exhibiting a similar clinical phenotype, have different neurophysiological learning processes, probably related to different pathophysiological mechanisms of migraine chronification.

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