Short term effect of intermittent negative pressure ventilation in COPD patients with respiratory failure

N. Ambrosino, T. Montagna, S. Nava, A. Negri, S. Brega, C. Fracchia, L. Zocchi, C. Rampulla

Research output: Contribution to journalArticlepeer-review


Ten patients with stable chronic obstructive pulmonary disease (COPD) and hypercapnic respiratory failure were randomly submitted to intermittent negative pressure ventilation (INPV) 6 h per day for 5 consecutive days by either a cuirass or pneumo wrap ventilator. The effects were assessed by measurements of spirometry, blood gases, maximal inspiratory (MIP) and expiratory (MEP) pressures, 12 minutes walking distance test (12 mwd), sensation of dyspnoea by a visual analogue scale (VAS) and diaphragmatic electromyographic activity (Edi). Edi was recorded during INPV sessions in only 7 patients. The same measurements apart from Edi were also performed in 8 matched control patients randomly submitted to conventional physiotherapy. During INPV, Edi activity was reduced, at least temporarily down to 50% of baseline values. Comparison of baseline with post INPV values showed no changes in thoracic gas volume (TGV), forced expiratory volume in one second (FEV1), FEV1/forced vital capacity (FVC), arterial oxygen partial pressure (Pao2) and MEP; significant improvements were seen in MIP, vital capacity (VC), VAS, and 12 mwd only in patients submitted to INPV. A significant improvement in PaCO2 was observed in both groups of patients. We conclude that INPV may be effective in improving the functional reserve of the inspiratory muscles in selected COPD patients with hypercapnic respiratory failure and signs of inspiratory muscle dysfunction.

Original languageEnglish
Pages (from-to)502-508
Number of pages7
JournalEuropean Respiratory Journal
Issue number5
Publication statusPublished - 1990


  • chronic obstructive pulmonary disease
  • inspiratory muscle fatigue
  • inspiratory muscle rest
  • mechanical ventilation
  • respiratory failure
  • respiratory physiotherapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Short term effect of intermittent negative pressure ventilation in COPD patients with respiratory failure'. Together they form a unique fingerprint.

Cite this