Short-term effect of octreotide on intraoesophageal variceal pressure: A double-blind placebo-controlled study

Massimo Primignani, Luca Carpinelli, Maria Clara Vazzoler, Maria Cremilda Hall De Lima, Angelika Nolte, Rosaria Marcelli, Roberto De Franchis

Research output: Contribution to journalArticle

Abstract

Objective: To perform a double-blind placebo-controlled study to evaluate the effect of 100 or 200 μg intravenous bolus doses of octreotide on intraoesophageal variceal pressure (IOVP) in cirrhotic patients. Participants: Eighteen patients with liver cirrhosis and previous variceal bleeding attending the Gastroenterology Unit at the University of Milan, Milan, Italy. Methods: IOVP was measured by a sclerotherapy needle; a second tracing from the oesophageal lumen was obtained to constantly express IOVP as transmural pressure. Eighteen patients were randomly allocated placebo or octreotide; three patients had IOVP measured twice, for a total of 21 tracings. The recording was continued for 5 min. Results: Basal IOVP in the three groups was not significantly different. After octreotide 100 or 200 μg, IOVP increased within 40 sec in all patients (37.7 and 38.5%, respectively) and remained persistently elevated over the 5-min recording in most of the patients. Placebo injection had no effect. Conclusion: The use of an intravenous octreotide bolus injection is not appropriate as a first-line therapy for variceal haemorrhage.

Original languageEnglish
Pages (from-to)1027-1031
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume6
Issue number11
Publication statusPublished - 1994

Keywords

  • Haemorrhage treatment
  • Oesophageal varices
  • Portal hypertension

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Fingerprint Dive into the research topics of 'Short-term effect of octreotide on intraoesophageal variceal pressure: A double-blind placebo-controlled study'. Together they form a unique fingerprint.

  • Cite this

    Primignani, M., Carpinelli, L., Vazzoler, M. C., De Lima, M. C. H., Nolte, A., Marcelli, R., & De Franchis, R. (1994). Short-term effect of octreotide on intraoesophageal variceal pressure: A double-blind placebo-controlled study. European Journal of Gastroenterology and Hepatology, 6(11), 1027-1031.