Objective: To perform a double-blind placebo-controlled study to evaluate the effect of 100 or 200 μg intravenous bolus doses of octreotide on intraoesophageal variceal pressure (IOVP) in cirrhotic patients. Participants: Eighteen patients with liver cirrhosis and previous variceal bleeding attending the Gastroenterology Unit at the University of Milan, Milan, Italy. Methods: IOVP was measured by a sclerotherapy needle; a second tracing from the oesophageal lumen was obtained to constantly express IOVP as transmural pressure. Eighteen patients were randomly allocated placebo or octreotide; three patients had IOVP measured twice, for a total of 21 tracings. The recording was continued for 5 min. Results: Basal IOVP in the three groups was not significantly different. After octreotide 100 or 200 μg, IOVP increased within 40 sec in all patients (37.7 and 38.5%, respectively) and remained persistently elevated over the 5-min recording in most of the patients. Placebo injection had no effect. Conclusion: The use of an intravenous octreotide bolus injection is not appropriate as a first-line therapy for variceal haemorrhage.
|Number of pages||5|
|Journal||European Journal of Gastroenterology and Hepatology|
|Publication status||Published - 1994|
- Haemorrhage treatment
- Oesophageal varices
- Portal hypertension
ASJC Scopus subject areas