Short-term effects of appropriate empirical antimicrobial treatment with ceftolozane/tazobactam in a swine model of nosocomial pneumonia

A. Motos, G. Li Bassi, F. Pagliara, L. Fernandez-Barat, H. Yang, E.A. Xiol, T. Senussi, F.A. Idone, C. Travierso, C. Chiurazzi, R. Amaro, M. Yang, J. Bobi, M. Rigol, D.P. Nicolau, G. Frigola, R. Cabrera, J. Ramirez, P. Pelosi, F. BlasiM. Antonelli, A. Artigas, J. Vila, M. Kollef, A. Torres

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article numbere01899-20
JournalAntimicrobial Agents and Chemotherapy
Volume65
Issue number2
DOIs
Publication statusPublished - 2021

Keywords

  • Animal models
  • Appropriate empirical antimicrobial treatment
  • Mechanical ventilation
  • Pneumonia
  • Pseudomonas aeruginosa
  • ceftolozane plus tazobactam
  • interleukin 1beta
  • interleukin 8
  • oxygen
  • piperacillin plus tazobactam
  • sodium chloride
  • antiinfective agent
  • ceftolozane
  • cephalosporin derivative
  • penicillanic acid
  • tazobactam
  • animal experiment
  • animal model
  • animal tissue
  • antibiotic resistance
  • antibiotic sensitivity
  • antibiotic therapy
  • antimicrobial therapy
  • area under the curve
  • Article
  • bacterial load
  • bactericidal activity
  • bronchoalveolar lavage fluid
  • clinical feature
  • colony forming unit
  • comparative study
  • controlled study
  • disease severity
  • down regulation
  • epithelial lining fluid
  • female
  • histopathology
  • hospital infection
  • lung burden
  • lung gas exchange
  • lung lavage fluid
  • lung lobe
  • lung mechanics
  • lung parenchyma
  • lung ventilation
  • microbiological examination
  • minimum inhibitory concentration
  • nonhuman
  • outcome assessment
  • oxygenation
  • plasma concentration-time curve
  • porcine model
  • priority journal
  • Pseudomonas pneumonia
  • qualitative analysis
  • quantitative analysis
  • volume of distribution
  • animal
  • cross infection
  • microbial sensitivity test
  • multidrug resistance
  • pig
  • Pseudomonas infection
  • Animals
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Cephalosporins
  • Cross Infection
  • Drug Resistance, Multiple, Bacterial
  • Healthcare-Associated Pneumonia
  • Microbial Sensitivity Tests
  • Penicillanic Acid
  • Pseudomonas Infections
  • Swine
  • Tazobactam

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