Short-term effects of glucagon-like peptide 1 (GLP-1) receptor agonists on fat distribution in patients with type 2 diabetes mellitus: an ultrasonography study

Susanna Morano, Elisabetta Romagnoli, Tiziana Filardi, Luciano Nieddu, Elisabetta Mandosi, Mara Fallarino, Irene Turinese, Mariangela Pia Dagostino, Andrea Lenzi, Vincenzo Carnevale

Research output: Contribution to journalArticle

Abstract

Aims: Glucagon-like peptide 1 receptor agonists (GLP-1 RA) induce weight loss and reduction in adipose tissue, but the effects of GLP-1 RA on the distribution of fat deposits have been poorly investigated. Methods: In 25 patients with type 2 diabetes (16 females and 9 males, mean age 63.5 ± 8.8 years), treated with GLP-1 RA (exenatide, n. 12; liraglutide, n.13), both before and 3 months after starting treatment, an abdominal ultrasonographic scan, with Doppler of renal arteries, and echocardiography were performed. Subcutaneous fat width (peri-umbilical and sub-xiphoid), deep fat deposits (pre-aortic, peri-renal, and epicardial), and renal resistive index (RI) were evaluated. Results: GLP-1 RA induced highly significant (p 

Original languageEnglish
Pages (from-to)727-732
Number of pages6
JournalActa Diabetologica
Volume52
Issue number4
DOIs
Publication statusPublished - Aug 25 2015

Keywords

  • Abdominal ultrasonography
  • Deep fat
  • Echocardiography
  • Glucagon-like peptide 1 receptor agonists
  • Subcutaneous fat
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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