Short-term effects of nasal proportional assist ventilation in patients with chronic hypercapnic respiratory insufficiency

N. Ambrosino, M. Vitacca, G. Polese, M. Pagani, K. Foglio, A. Rossi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Proportional assist ventilation (PAV) has recently been proposed as a mode of synchronized partial ventilatory support. This study evaluates the short-term effects of nasal PAV on arterial blood gases in stable patients with chronic hypercapnia. Forty two patients (30 with chronic obstructive pulmonary disease (COPD) and 12 with restrictive chest wall disease (RCWD) due to kyphoscoliosis) underwent a 1 h run of nasal PAV. Randomly, two levels of assistance were performed: 1) PAV was set at a level corresponding to volume assist (VA) and flow assist (FA) at 80% of the individual values of elastance (Ers) and resistance (Rrs) obtained with the 'runaway' method; and 2) VA. and FA were set at a value corresponding to the difference between the patients' individual Ers and Rrs and normal values of Ers and Rrs. Arterial blood gases and dyspnoea (by visual analogue scale (VAS)) were evaluated in all patients during unsupported ventilation and 60 min of PAV. PAV was well tolerated and resulted in significant improvement in arterial oxygen tension (Pa,O2), arterial carbon dioxide tension (Pa,CO2) (6.8 ± 0.8 to 7.4 ± 1.4 and 7.2 ± 0.9 to 6.8 ± 09 kPa: respectively) and VAS (29 ± 23 to 20 ± 18%). The effects of PAV were not different in the two groups of diseases nor in the two groups of settings. Different settings of nasal proportional assist ventilation are well tolerated and may improve gas exchange and dyspnoea in patients with stable hypercapnic respiratory insufficiency.

Original languageEnglish
Pages (from-to)2829-2834
Number of pages6
JournalEuropean Respiratory Journal
Volume10
Issue number12
DOIs
Publication statusPublished - 1997

Fingerprint

Interactive Ventilatory Support
Nose
Respiratory Insufficiency
Gases
Visual Analog Scale
Dyspnea
Homeless Youth
Hypercapnia
Thoracic Wall
Carbon Dioxide
Chronic Obstructive Pulmonary Disease
Ventilation
Arterial Pressure
Reference Values
Oxygen

Keywords

  • Chest wall disease
  • Chronic obstructive pulmonary disease
  • Mechanical ventilation
  • Respiratory muscles

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Short-term effects of nasal proportional assist ventilation in patients with chronic hypercapnic respiratory insufficiency. / Ambrosino, N.; Vitacca, M.; Polese, G.; Pagani, M.; Foglio, K.; Rossi, A.

In: European Respiratory Journal, Vol. 10, No. 12, 1997, p. 2829-2834.

Research output: Contribution to journalArticle

Ambrosino, N. ; Vitacca, M. ; Polese, G. ; Pagani, M. ; Foglio, K. ; Rossi, A. / Short-term effects of nasal proportional assist ventilation in patients with chronic hypercapnic respiratory insufficiency. In: European Respiratory Journal. 1997 ; Vol. 10, No. 12. pp. 2829-2834.
@article{75780af36e6e4da7bbf69ed0cff27604,
title = "Short-term effects of nasal proportional assist ventilation in patients with chronic hypercapnic respiratory insufficiency",
abstract = "Proportional assist ventilation (PAV) has recently been proposed as a mode of synchronized partial ventilatory support. This study evaluates the short-term effects of nasal PAV on arterial blood gases in stable patients with chronic hypercapnia. Forty two patients (30 with chronic obstructive pulmonary disease (COPD) and 12 with restrictive chest wall disease (RCWD) due to kyphoscoliosis) underwent a 1 h run of nasal PAV. Randomly, two levels of assistance were performed: 1) PAV was set at a level corresponding to volume assist (VA) and flow assist (FA) at 80{\%} of the individual values of elastance (Ers) and resistance (Rrs) obtained with the 'runaway' method; and 2) VA. and FA were set at a value corresponding to the difference between the patients' individual Ers and Rrs and normal values of Ers and Rrs. Arterial blood gases and dyspnoea (by visual analogue scale (VAS)) were evaluated in all patients during unsupported ventilation and 60 min of PAV. PAV was well tolerated and resulted in significant improvement in arterial oxygen tension (Pa,O2), arterial carbon dioxide tension (Pa,CO2) (6.8 ± 0.8 to 7.4 ± 1.4 and 7.2 ± 0.9 to 6.8 ± 09 kPa: respectively) and VAS (29 ± 23 to 20 ± 18{\%}). The effects of PAV were not different in the two groups of diseases nor in the two groups of settings. Different settings of nasal proportional assist ventilation are well tolerated and may improve gas exchange and dyspnoea in patients with stable hypercapnic respiratory insufficiency.",
keywords = "Chest wall disease, Chronic obstructive pulmonary disease, Mechanical ventilation, Respiratory muscles",
author = "N. Ambrosino and M. Vitacca and G. Polese and M. Pagani and K. Foglio and A. Rossi",
year = "1997",
doi = "10.1183/09031936.97.10122829",
language = "English",
volume = "10",
pages = "2829--2834",
journal = "European Journal of Respiratory Diseases",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "12",

}

TY - JOUR

T1 - Short-term effects of nasal proportional assist ventilation in patients with chronic hypercapnic respiratory insufficiency

AU - Ambrosino, N.

AU - Vitacca, M.

AU - Polese, G.

AU - Pagani, M.

AU - Foglio, K.

AU - Rossi, A.

PY - 1997

Y1 - 1997

N2 - Proportional assist ventilation (PAV) has recently been proposed as a mode of synchronized partial ventilatory support. This study evaluates the short-term effects of nasal PAV on arterial blood gases in stable patients with chronic hypercapnia. Forty two patients (30 with chronic obstructive pulmonary disease (COPD) and 12 with restrictive chest wall disease (RCWD) due to kyphoscoliosis) underwent a 1 h run of nasal PAV. Randomly, two levels of assistance were performed: 1) PAV was set at a level corresponding to volume assist (VA) and flow assist (FA) at 80% of the individual values of elastance (Ers) and resistance (Rrs) obtained with the 'runaway' method; and 2) VA. and FA were set at a value corresponding to the difference between the patients' individual Ers and Rrs and normal values of Ers and Rrs. Arterial blood gases and dyspnoea (by visual analogue scale (VAS)) were evaluated in all patients during unsupported ventilation and 60 min of PAV. PAV was well tolerated and resulted in significant improvement in arterial oxygen tension (Pa,O2), arterial carbon dioxide tension (Pa,CO2) (6.8 ± 0.8 to 7.4 ± 1.4 and 7.2 ± 0.9 to 6.8 ± 09 kPa: respectively) and VAS (29 ± 23 to 20 ± 18%). The effects of PAV were not different in the two groups of diseases nor in the two groups of settings. Different settings of nasal proportional assist ventilation are well tolerated and may improve gas exchange and dyspnoea in patients with stable hypercapnic respiratory insufficiency.

AB - Proportional assist ventilation (PAV) has recently been proposed as a mode of synchronized partial ventilatory support. This study evaluates the short-term effects of nasal PAV on arterial blood gases in stable patients with chronic hypercapnia. Forty two patients (30 with chronic obstructive pulmonary disease (COPD) and 12 with restrictive chest wall disease (RCWD) due to kyphoscoliosis) underwent a 1 h run of nasal PAV. Randomly, two levels of assistance were performed: 1) PAV was set at a level corresponding to volume assist (VA) and flow assist (FA) at 80% of the individual values of elastance (Ers) and resistance (Rrs) obtained with the 'runaway' method; and 2) VA. and FA were set at a value corresponding to the difference between the patients' individual Ers and Rrs and normal values of Ers and Rrs. Arterial blood gases and dyspnoea (by visual analogue scale (VAS)) were evaluated in all patients during unsupported ventilation and 60 min of PAV. PAV was well tolerated and resulted in significant improvement in arterial oxygen tension (Pa,O2), arterial carbon dioxide tension (Pa,CO2) (6.8 ± 0.8 to 7.4 ± 1.4 and 7.2 ± 0.9 to 6.8 ± 09 kPa: respectively) and VAS (29 ± 23 to 20 ± 18%). The effects of PAV were not different in the two groups of diseases nor in the two groups of settings. Different settings of nasal proportional assist ventilation are well tolerated and may improve gas exchange and dyspnoea in patients with stable hypercapnic respiratory insufficiency.

KW - Chest wall disease

KW - Chronic obstructive pulmonary disease

KW - Mechanical ventilation

KW - Respiratory muscles

UR - http://www.scopus.com/inward/record.url?scp=0031464625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031464625&partnerID=8YFLogxK

U2 - 10.1183/09031936.97.10122829

DO - 10.1183/09031936.97.10122829

M3 - Article

C2 - 9493669

AN - SCOPUS:0031464625

VL - 10

SP - 2829

EP - 2834

JO - European Journal of Respiratory Diseases

JF - European Journal of Respiratory Diseases

SN - 0903-1936

IS - 12

ER -