Short-term effects of surgery in post-menopausal patients with primary hyperparathyroidism and normal bone turnover

V. Carnevale, M. T. Pacitti, M. Pileri, F. Paglia, A. Scillitani, S. Dionisi, P. Caravella, E. Romagnoli, S. Minisola

Research output: Contribution to journalArticle

Abstract

The most common clinical presentation of primary hyperparathyroidism (PHPT) is nowadays characterized by a slight skeletal involvement. We studied 5 consecutive female patients with PHPT presenting with bone turnover marker levels within the reference range of our Center and whose bone mineral density values were above the usual fracture risk threshold. In each patient we measured, both in basal conditions and daily, for the first 5 days after surgery, the following indexes: serum total (T-ALP) and bone-specific (B-ALP) alkaline phosphatase activity, osteocalcin (BGP, by two different assays), together with the 24-hour urinary excretions of total pyridinoline (Pyr/Cr) and deoxypyridinoline (D-Pyr/Cr), free deoxypyridinoline (FD-Pyr/Cr), cross-linked N-telopeptide of type I collagen (NTx/Cr), and type I C-telopeptide (CTx/Cr). The markers of both bone formation and resorption significantly decreased after surgery (p

Original languageEnglish
Pages (from-to)575-579
Number of pages5
JournalJournal of Endocrinological Investigation
Volume24
Issue number8
Publication statusPublished - 2001

Keywords

  • Bone turnover markers
  • Parathyroidectomy
  • Primary hyperparathyroidism

ASJC Scopus subject areas

  • Endocrinology

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    Carnevale, V., Pacitti, M. T., Pileri, M., Paglia, F., Scillitani, A., Dionisi, S., Caravella, P., Romagnoli, E., & Minisola, S. (2001). Short-term effects of surgery in post-menopausal patients with primary hyperparathyroidism and normal bone turnover. Journal of Endocrinological Investigation, 24(8), 575-579.