Short-term effects of thyroid hormone in prenatal development and cell differentiation

Sandra Incerpi, Sergio Scapin, Silvia D'Arezzo, Silvana Spagnuolo, Silvia Leoni

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Extranuclear or nongenomic effects of thyroid hormones do not require interaction with the nuclear receptor, but are probably mediated by specific membrane receptors. This review will focus on the extranuclear effects of thyroid hormones on plasma membrane transport systems in non mammalian cells: chick embryo hepatocytes at two different stages of development, 14 and 19 days. At variance with mammals, the chick embryo develops in a closed compartment, beyond the influence of maternal endocrine factors. Thyroid hormones inhibit the Na+/K+-ATPase but stimulate the Na+/H + exchanger and amino acid transport System A with different dose-responses: a bell-shaped curve in the case of the exchanger and a classic saturation curve in the case of System A. These effects are mimicked by the analog 3,5-diiodothyronine. Signal transduction is mediated by interplay among kinases, mainly protein kinase C and the MAPK pathway, initially primed by second messengers such as Ca2+, IP3, and DAG as in mammalian cells. Thyroid hormones and 3,5-diiodothyronine stimulate thymidine incorporation and DNA synthesis, associated with the increased levels and activity of cyclins and cyclin-dependent kinases involved in the G1/S transition, and also these effects have their starting point at the plasma membrane. Increasing evidence now demonstrates that thyroid hormones act as growth factors for chick embryo hepatocytes and their extranuclear effects are important for prenatal development and differentiation.

Original languageEnglish
Pages (from-to)434-443
Number of pages10
JournalSteroids
Volume70
Issue number5-7 SPEC. ISS.
DOIs
Publication statusPublished - May 2005

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Thyroid Hormones
Cell Differentiation
Chick Embryo
Cell membranes
Hepatocytes
Amino Acid Transport System A
Cells
Cell Membrane
Signal transduction
Sodium-Hydrogen Antiporter
Cyclins
Mammals
Cyclin-Dependent Kinases
Second Messenger Systems
Cytoplasmic and Nuclear Receptors
Thymidine
Signal Transduction
Intercellular Signaling Peptides and Proteins
Mothers
Membranes

Keywords

  • 3,5-Diiodothyronine
  • Amino acid transport
  • Chick embryo hepatocyte
  • Ion transport
  • Thyroid hormone

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Cite this

Short-term effects of thyroid hormone in prenatal development and cell differentiation. / Incerpi, Sandra; Scapin, Sergio; D'Arezzo, Silvia; Spagnuolo, Silvana; Leoni, Silvia.

In: Steroids, Vol. 70, No. 5-7 SPEC. ISS., 05.2005, p. 434-443.

Research output: Contribution to journalArticle

Incerpi, Sandra ; Scapin, Sergio ; D'Arezzo, Silvia ; Spagnuolo, Silvana ; Leoni, Silvia. / Short-term effects of thyroid hormone in prenatal development and cell differentiation. In: Steroids. 2005 ; Vol. 70, No. 5-7 SPEC. ISS. pp. 434-443.
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