Short-term evolution of individual enhancing MS studied with magnetization transfer imaging

Massimo Filippi, Maria A. Rocca, Maria P. Sormani, Clodoaldo Pereira, Giancarlo Comi

Research output: Contribution to journalArticlepeer-review


We performed serial monthly magnetization transfer (MT) imaging to evaluate the prevalence and evolution of structural changes in individual enhancing lesions from patients with multiple sclerosis (MS). Every 4 weeks for 3 months, we obtained dual echo, magnetization transfer (MT) imaging and, 5 min after SD (0.1 mmol/kg) gadolinium-DTPA injection, T1-weighted scans from 10 patients with early relapsing-remitting MS. We measured the MT ratio (MTR) of enhancing lesions seen on the entry scans on co-registered quantitative MTR images at entry and during the follow up. Fourty-two enhancing lesions were identified on the entry scans. According to the 'maximal random fluctuation' detected for the normal-appearing white matter MTR values, 16 (38%) lesions were classified as 'increasing MTR' lesions, 21 (50%) as 'stable MTR' lesions, and 5 (12%) as 'decreasing MTR' lesions. The classification of the lesions after the first month of follow up strongly predicted the classification at the end of the follow up (chi squared = 20.35, p = 0.0004). These results indicate that the enhancing lesion population in MS is heterogeneous, and that reparative mechanisms occurring after blood-brain barrier opening are not efficient in only a minority of the enhancing lesions from patients with early relapsing-remitting MS.

Original languageEnglish
Pages (from-to)979-984
Number of pages6
JournalMagnetic Resonance Imaging
Issue number7
Publication statusPublished - Sep 1999


  • Gadolinium-DTPA
  • Magnetization transfer ratio
  • Multiple sclerosis

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics


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