Short-term HIIT and Fatmax training increase aerobic and metabolic fitness in men with class II and III obesity

Stefano Lanzi, Franco Codecasa, Mauro Cornacchia, Sabrina Maestrini, Paolo Capodaglio, Amelia Brunani, Paolo Fanari, Alberto Salvadori, Davide Malatesta

Research output: Contribution to journalArticlepeer-review


Objective To compare the effects of two different 2-week-long training modalities [continuous at the intensity eliciting the maximal fat oxidation (Fatmax) versus high-intensity interval training (HIIT)] in men with class II and III obesity. Methods Nineteen men with obesity (BMI ≥ 35 kg.m-2) were assigned to Fatmax group (GFatmax) or to HIIT group (GHIIT). Both groups performed eight cycling sessions matched for mechanical work. Aerobic fitness and fat oxidation rates (FORs) during exercise were assessed prior and following the training. Blood samples were drawn to determine hormones and plasma metabolites levels. Insulin resistance was assessed by the homeostasis model assessment of insulin resistance (HOMA2-IR). Results Aerobic fitness and FORs during exercise were significantly increased in both groups after training (P ≤ 0.001). HOMA2-IR was significantly reduced only for GFatmax (P ≤ 0.001). Resting non-esterified fatty acids (NEFA) and insulin decreased significantly only in GFatmax (P ≤ 0.002). Conclusions Two weeks of HIIT and Fatmax training are effective for the improvement of aerobic fitness and FORs during exercise in these classes of obesity. The decreased levels of resting NEFA only in GFatmax may be involved in the decreased insulin resistance only in this group.

Original languageEnglish
Pages (from-to)1987-1994
Number of pages8
Issue number10
Publication statusPublished - Oct 1 2015

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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