Short-term intravenous citalopram augmentation in partial/nonresponders with major depression: A randomized placebo-controlled study

Alfredo Carlo Altamura, Bernardo DellOsso, Massimiliano Buoli, Monica Bosi, Emanuela Mundo

Research output: Contribution to journalArticlepeer-review

Abstract

Approximately 30-45% of patients with major depressive episode (MDE) do not fully respond to standard recommended treatments and further strategies of intervention, including pharmacological augmentation, have been proposed for these patients. This study was aimed to evaluate the efficacy of short-term, low-dose (10 mg/day) intravenous (i.v.) citalopram augmentation versus placebo in a sample of patients with MDE and partial or no response to selective serotonin reuptake inhibitors (SSRIs). Thirty-six patients with a Diagnostic and Statistical Manual for Mental Disorders, 4th edition, text revision criteria MDE and partial or no response to oral SSRIs were selected and randomly assigned to citalopram (n=18) or to placebo (n=18) i.v. augmentation. The augmentation regimen lasted 5 consecutive days during which the patients were maintained on their current treatment with oral SSRIs. Analyses of variance with repeated measures on Hamilton Depression Rating Scale and Montgomery-Asberg Depression Rating Scale total scores, administered daily with blind-raters conditions, were done. With regard to the Hamilton Depression Rating Scale total scores, a significant time effect (F=42.02, P

Original languageEnglish
Pages (from-to)198-202
Number of pages5
JournalInternational Clinical Psychopharmacology
Volume23
Issue number4
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Augmentation
  • Intravenous citalopram
  • Major depressive episode
  • Selective serotonin reuptake inhibitors
  • Treatment response

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health

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