Short-Term Liver Function after Biliopancreatic Diversion

Francesco Papadia, Giuseppe M. Marinari, Giovanni Camerini, Gian Franco Adami, Federica Murelli, Flavia Carlini, Cesare Stabilini, Nicola Scopinaro

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Liver failure after biliopancreatic diversion (BPD) has been reported. Although in our series of 2,515 BPD with a minimum follow-up of 12 months we have never observed this complication, a transitory and significant rise in serum AST and ALT has been detected in some cases, suggesting the occurrence of transient liver damage. To assess if risk factors for acute liver damage after BPD could be identified, we studied the evolution of hepatic biochemistry in a sample of our operated subjects. Methods: We studied 99 consecutive patients submitted to the same type of BPD (ad hoc stomach, ad hoc alimentary limb). Patients with a history of alcohol consumption or positive hepatic serology were excluded. Preoperative body weight (BW), body mass index (BMI), excess weight (EW), % excess weight (%EW), fasting serum glucose level (SG), hepatic histology (HI), weight loss (WL) at 2, 4 and 12 months, and excess weight % loss (IEW%L) at the same time were correlated with preoperative and 2, 4 and 12 months hepatic biochemistry. Results: Compared with preoperative values, AST levels at 2 months significantly increased (Student's t-test, P=0.0003) and significantly decreased at 12 months (P=0.0001). Spearman's Rank test showed significant correlations between 2 months AST levels and WL at 2 months (P=0.005), preoperative BW (P

Original languageEnglish
Pages (from-to)752-755
Number of pages4
JournalObesity Surgery
Volume13
Issue number5
DOIs
Publication statusPublished - Oct 2003

Keywords

  • Bariatric surgery
  • Biliopancreatic diversion
  • Hepatic dysfunction
  • Morbid obesity

ASJC Scopus subject areas

  • Surgery

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