Short-term outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Preliminary analysis of a multicentre study

Antonio Macrì, Vincenzo Arcoraci, Valerio Belgrano, Marina Caldana, Tommaso Cioppa, Barbara Costantini, Eugenio Cucinotta, Franco De Cian, Pierandrea De Iaco, Giovanni De Manzoni, Angelo Di Giorgio, Francesco Fleres, Francesca Muffatti, Elena Orsenigo, Antonio Daniele Pinna, Franco Roviello, Paolo Sammartino, Giovanni Scambia, Edoardo Saladino

Research output: Contribution to journalArticle

Abstract

Aim: To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy. Patients and Methods: A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis. Results: In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity. Conclusion: Careful patient selection has to be performed to improve clinical outcomes.

Original languageEnglish
Pages (from-to)5689-5693
Number of pages5
JournalAnticancer Research
Volume34
Issue number10
Publication statusPublished - Oct 1 2014

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Keywords

  • Cytoreductive surgery
  • HIPEC
  • Hyperthermia
  • Morbidity
  • Mortality

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Macrì, A., Arcoraci, V., Belgrano, V., Caldana, M., Cioppa, T., Costantini, B., Cucinotta, E., De Cian, F., De Iaco, P., De Manzoni, G., Di Giorgio, A., Fleres, F., Muffatti, F., Orsenigo, E., Daniele Pinna, A., Roviello, F., Sammartino, P., Scambia, G., & Saladino, E. (2014). Short-term outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Preliminary analysis of a multicentre study. Anticancer Research, 34(10), 5689-5693.