Short-term plastic changes of the human nociceptive system following acute pain induced by capsaicin

Massimiliano Valeriani, Lars Arendt-Nielsen, Domenica Le Pera, Domenico Restuccia, Tiziana Rosso, Liala De Armas, Toni Maiese, Antonio Fiaschi, Pietro Tonali, Michele Tinazzi

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective: To investigate possible neuroplastic changes induced by pain in cerebral areas devoted to nociceptive input processing. Methods: CO2 laser-evoked potentials (LEPs) were recorded from 10 healthy subjects after stimulation of the right and left hand dorsum. Acute pain was obtained by topical application of capsaicin on the skin of right hand dorsum. LEPs were recorded after right and left hand stimulation before capsaicin, at the peak pain and 10-20 min after capsaicin removal. Right hand LEPs were evoked by laser stimuli delivered over the zone of secondary hyperalgesia during capsaicin and on both the zones of primary and secondary hyperalgesia after capsaicin removal. Results: After right hand stimulation, the vertex LEPs, which are generated in the cingulate cortex, were significantly decreased in amplitude during capsaicin application and after capsaicin removal. Moreover, the topography of these potentials was modified after capsaicin removal, shifting from the central toward the parietal region. Dipolar modelling showed that the dipolar source in the anterior cingulate cortex moved backward after capsaicin removal. All these changes were not observed after stimulation of the left hand, contralateral to the application of capsaicin, thus suggesting that functional changes are selective for the painful skin and the adjacent territories. Conclusions: Our results suggest that acute cutaneous pain may inhibit the neural activity in regions of central nervous system processing nociceptive inputs and cortical representation of these inputs can be rapidly modified in presence of acute pain.

Original languageEnglish
Pages (from-to)1879-1890
Number of pages12
JournalClinical Neurophysiology
Volume114
Issue number10
DOIs
Publication statusPublished - Oct 2003

Fingerprint

Capsaicin
Acute Pain
Hand
Hyperalgesia
Gyrus Cinguli
Skin
Pain
Parietal Lobe
Gas Lasers
Healthy Volunteers
Lasers
Central Nervous System
Laser-Evoked Potentials

Keywords

  • Central nervous system
  • Dipolar modelling
  • Human brain
  • Hyperalgesia
  • Pain
  • Plasticity

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Short-term plastic changes of the human nociceptive system following acute pain induced by capsaicin. / Valeriani, Massimiliano; Arendt-Nielsen, Lars; Le Pera, Domenica; Restuccia, Domenico; Rosso, Tiziana; De Armas, Liala; Maiese, Toni; Fiaschi, Antonio; Tonali, Pietro; Tinazzi, Michele.

In: Clinical Neurophysiology, Vol. 114, No. 10, 10.2003, p. 1879-1890.

Research output: Contribution to journalArticle

Valeriani, M, Arendt-Nielsen, L, Le Pera, D, Restuccia, D, Rosso, T, De Armas, L, Maiese, T, Fiaschi, A, Tonali, P & Tinazzi, M 2003, 'Short-term plastic changes of the human nociceptive system following acute pain induced by capsaicin', Clinical Neurophysiology, vol. 114, no. 10, pp. 1879-1890. https://doi.org/10.1016/S1388-2457(03)00180-9
Valeriani, Massimiliano ; Arendt-Nielsen, Lars ; Le Pera, Domenica ; Restuccia, Domenico ; Rosso, Tiziana ; De Armas, Liala ; Maiese, Toni ; Fiaschi, Antonio ; Tonali, Pietro ; Tinazzi, Michele. / Short-term plastic changes of the human nociceptive system following acute pain induced by capsaicin. In: Clinical Neurophysiology. 2003 ; Vol. 114, No. 10. pp. 1879-1890.
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AU - Rosso, Tiziana

AU - De Armas, Liala

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AB - Objective: To investigate possible neuroplastic changes induced by pain in cerebral areas devoted to nociceptive input processing. Methods: CO2 laser-evoked potentials (LEPs) were recorded from 10 healthy subjects after stimulation of the right and left hand dorsum. Acute pain was obtained by topical application of capsaicin on the skin of right hand dorsum. LEPs were recorded after right and left hand stimulation before capsaicin, at the peak pain and 10-20 min after capsaicin removal. Right hand LEPs were evoked by laser stimuli delivered over the zone of secondary hyperalgesia during capsaicin and on both the zones of primary and secondary hyperalgesia after capsaicin removal. Results: After right hand stimulation, the vertex LEPs, which are generated in the cingulate cortex, were significantly decreased in amplitude during capsaicin application and after capsaicin removal. Moreover, the topography of these potentials was modified after capsaicin removal, shifting from the central toward the parietal region. Dipolar modelling showed that the dipolar source in the anterior cingulate cortex moved backward after capsaicin removal. All these changes were not observed after stimulation of the left hand, contralateral to the application of capsaicin, thus suggesting that functional changes are selective for the painful skin and the adjacent territories. Conclusions: Our results suggest that acute cutaneous pain may inhibit the neural activity in regions of central nervous system processing nociceptive inputs and cortical representation of these inputs can be rapidly modified in presence of acute pain.

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