Valutazione prognostica a breve termine dell'infarto miocardico acuto: confronto tra l'ecocardiografia bidimensionale, l'ECG e il CPK-MB.

Translated title of the contribution: Short-term prognostic evaluation of acute myocardial infarct: comparison of 2-dimensional echocardiography, electrocardiography, and the MB-CK index

G. Sarasso, D. Aralda, J. Makmur, G. Francalacci, R. Campini, L. Righi, P. Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

To compare the non-invasive methods of quantification of acute myocardial infarction (AMI) [two dimensional echocardiography (2DE), standard 12-leads ECG, and enzymatic indices as MB-CK peak activity and MB-CK time activity curve expressed by an extension index (EI-MBCK)] in relation to their prognostic value, 79 patients with a first AMI were evaluated. We have observed in a three months follow-up a total mortality of 12.6%. The infarct size, calculated echocardiographically by a segment score, was correlated with the number of pathological Q waves in the standard ECG (rho= 0.83). Peak MB-CK enzyme and EI-MBCK correlated both with the segment score, but with a lower correlation coefficient (rho= 0.67). To identify patients at different risk, discriminant analysis was used which gave the following limit values for the patients at a very high risk: 2DE score = 17; number of Q waves = 7; peak MB-CK = 176 U/L; EI-MBCK = 54 grEq/m2; for the patients at a very low risk: score = 6; number of Q waves = 2; peak MB-CK = 35; EI-MBCK = 15. To verify if the association of these different techniques could improve the predictivity, a discriminant bivariate function analysis with three variables was calculated. The resulting equation was: Z = 2.31 X 2DE score + 8.59 X number of Q waves - 0.23 X peak MB-CK. Changing peak MB-CK value with EI-MBCK did not improve the statistical significativity. The results have confirmed that the integration of all the three variables improved the prognostic predictivity. According to the risk Z obtained, the patients were allocated into classes of different risk: values of Z greater than 57 or less than 18 could identify patients respectively at a very high or at a very low risk. For values between 37 and 42 the prognosis remains uncertain. Among the three variables, 2DE and ECG showed an equivalent prognostic accuracy, whereas enzyme indices had a lower prognostic influence, especially in the presence of large infarcts. Thus, 2DE, ECG and enzyme indices can identify patients at increased risk; the individual method seems to be inadequate; to obtain valid predictive informations it is necessary to integrate all the three non invasive techniques.

Translated title of the contributionShort-term prognostic evaluation of acute myocardial infarct: comparison of 2-dimensional echocardiography, electrocardiography, and the MB-CK index
Original languageItalian
Pages (from-to)11-20
Number of pages10
JournalGiornale Italiano di Cardiologia
Volume13
Issue number7
Publication statusPublished - Jul 1983

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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