Short-term prophylaxis with deoxyspergualin prevents testicular autoimmunity in mice

Maira Ablake, Masahiro Itoh, Tetsushi Kaneko, Akira Iimura, Yoichi Nakamura, Pierluigi Meroni, Ferdinando Nicoletti

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of the treatment with the immunosuppressant deoxyspergualin on the development of experimental autoimmune orchitis were studied. The results showed that C3H/He mice immunized with testicular germ cells and treated daily with either 0.3 or 3 mg/kg body weight deoxyspergualin during days 15-20 post-immunization developed experimental autoimmune orchitis lesions with a significantly lower incidence and severity than did the control mice treated under the same experimental conditions with phosphate buffered saline (PBS). The effects of deoxyspergualin were clearly dose-dependent, and the higher dose of the drug also markedly reduced the degree of delayed type hypersensitivity responses against testicular germ cells. These data suggest that deoxyspergualin may be worthy of consideration for the prevention/treatment of human immunoinflammatory orchitis.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalEuropean Journal of Pharmacology
Volume450
Issue number2
DOIs
Publication statusPublished - Aug 23 2002

Keywords

  • Autoimmunity
  • Deoxyspergualin
  • Immunotherapy
  • Orchitis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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