Short-term prophylaxis with deoxyspergualin prevents testicular autoimmunity in mice

Maira Ablake, Masahiro Itoh, Tetsushi Kaneko, Akira Iimura, Yoichi Nakamura, Pierluigi Meroni, Ferdinando Nicoletti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of the treatment with the immunosuppressant deoxyspergualin on the development of experimental autoimmune orchitis were studied. The results showed that C3H/He mice immunized with testicular germ cells and treated daily with either 0.3 or 3 mg/kg body weight deoxyspergualin during days 15-20 post-immunization developed experimental autoimmune orchitis lesions with a significantly lower incidence and severity than did the control mice treated under the same experimental conditions with phosphate buffered saline (PBS). The effects of deoxyspergualin were clearly dose-dependent, and the higher dose of the drug also markedly reduced the degree of delayed type hypersensitivity responses against testicular germ cells. These data suggest that deoxyspergualin may be worthy of consideration for the prevention/treatment of human immunoinflammatory orchitis.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalEuropean Journal of Pharmacology
Volume450
Issue number2
DOIs
Publication statusPublished - Aug 23 2002

Fingerprint

Orchitis
Autoimmunity
Germ Cells
Inbred C3H Mouse
Delayed Hypersensitivity
Immunosuppressive Agents
Immunization
Phosphates
Body Weight
gusperimus
Incidence
Therapeutics
Pharmaceutical Preparations

Keywords

  • Autoimmunity
  • Deoxyspergualin
  • Immunotherapy
  • Orchitis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Short-term prophylaxis with deoxyspergualin prevents testicular autoimmunity in mice. / Ablake, Maira; Itoh, Masahiro; Kaneko, Tetsushi; Iimura, Akira; Nakamura, Yoichi; Meroni, Pierluigi; Nicoletti, Ferdinando.

In: European Journal of Pharmacology, Vol. 450, No. 2, 23.08.2002, p. 209-212.

Research output: Contribution to journalArticle

Ablake, Maira ; Itoh, Masahiro ; Kaneko, Tetsushi ; Iimura, Akira ; Nakamura, Yoichi ; Meroni, Pierluigi ; Nicoletti, Ferdinando. / Short-term prophylaxis with deoxyspergualin prevents testicular autoimmunity in mice. In: European Journal of Pharmacology. 2002 ; Vol. 450, No. 2. pp. 209-212.
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