Short-Term Repeatability of Noninvasive Aortic Pulse Wave Velocity Assessment

Comparison Between Methods and Devices

Andrea Grillo, Gianfranco Parati, Matteo Rovina, Francesco Moretti, Lucia Salvi, Lan Gao, Corrado Baldi, Giovanni Sorropago, Andrea Faini, Sandrine C Millasseau, Filippo Scalise, Renzo Carretta, Paolo Salvi

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Aortic pulse wave velocity (PWV) is an indirect index of arterial stiffness and an independent cardiovascular risk factor. Consistency of PWV assessment over time is thus an essential feature for its clinical application. However, studies providing a comparative estimate of the reproducibility of PWV across different noninvasive devices are lacking, especially in the elderly and in individuals at high cardiovascular risk.

METHODS: Aimed at filling this gap, short-term repeatability of PWV, estimated with 6 different devices (Complior Analyse, PulsePen-ETT, PulsePen-ET, SphygmoCor Px/Vx, BPLab, and Mobil-O-Graph), was evaluated in 102 high cardiovascular risk patients hospitalized for suspected coronary artery disease (72 males, 65 ± 13 years). PWV was measured in a single session twice, at 15-minute interval, and its reproducibility was assessed though coefficient of variation (CV), coefficient of repeatability, and intraclass correlation coefficient.

RESULTS: The CV of PWV, measured with any of these devices, was <10%. Repeatability was higher with cuff-based methods (BPLab: CV = 5.5% and Mobil-O-Graph: CV = 3.4%) than with devices measuring carotid-femoral PWV (Complior: CV = 8.2%; PulsePen-TT: CV = 8.0%; PulsePen-ETT: CV = 5.8%; and SphygmoCor: CV = 9.5%). In the latter group, PWV repeatability was lower in subjects with higher carotid-femoral PWV. The differences in PWV between repeated measurements, except for the Mobil-O-Graph, did not depend on short-term variations of mean blood pressure or heart rate.

CONCLUSIONS: Our study shows that the short-term repeatability of PWV measures is good but not homogenous across different devices and at different PWV values. These findings, obtained in patients at high cardiovascular risk, may be relevant when evaluating the prognostic importance of PWV.

Original languageEnglish
Pages (from-to)80-88
Number of pages9
JournalAmerican Journal of Hypertension
Volume31
Issue number1
DOIs
Publication statusPublished - Dec 8 2017

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Pulse Wave Analysis
Equipment and Supplies
Thigh
Vascular Stiffness
Coronary Artery Disease

Keywords

  • Journal Article

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Short-Term Repeatability of Noninvasive Aortic Pulse Wave Velocity Assessment : Comparison Between Methods and Devices. / Grillo, Andrea; Parati, Gianfranco; Rovina, Matteo; Moretti, Francesco; Salvi, Lucia; Gao, Lan; Baldi, Corrado; Sorropago, Giovanni; Faini, Andrea; Millasseau, Sandrine C; Scalise, Filippo; Carretta, Renzo; Salvi, Paolo.

In: American Journal of Hypertension, Vol. 31, No. 1, 08.12.2017, p. 80-88.

Research output: Contribution to journalArticle

Grillo, A, Parati, G, Rovina, M, Moretti, F, Salvi, L, Gao, L, Baldi, C, Sorropago, G, Faini, A, Millasseau, SC, Scalise, F, Carretta, R & Salvi, P 2017, 'Short-Term Repeatability of Noninvasive Aortic Pulse Wave Velocity Assessment: Comparison Between Methods and Devices', American Journal of Hypertension, vol. 31, no. 1, pp. 80-88. https://doi.org/10.1093/ajh/hpx140
Grillo, Andrea ; Parati, Gianfranco ; Rovina, Matteo ; Moretti, Francesco ; Salvi, Lucia ; Gao, Lan ; Baldi, Corrado ; Sorropago, Giovanni ; Faini, Andrea ; Millasseau, Sandrine C ; Scalise, Filippo ; Carretta, Renzo ; Salvi, Paolo. / Short-Term Repeatability of Noninvasive Aortic Pulse Wave Velocity Assessment : Comparison Between Methods and Devices. In: American Journal of Hypertension. 2017 ; Vol. 31, No. 1. pp. 80-88.
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abstract = "BACKGROUND: Aortic pulse wave velocity (PWV) is an indirect index of arterial stiffness and an independent cardiovascular risk factor. Consistency of PWV assessment over time is thus an essential feature for its clinical application. However, studies providing a comparative estimate of the reproducibility of PWV across different noninvasive devices are lacking, especially in the elderly and in individuals at high cardiovascular risk.METHODS: Aimed at filling this gap, short-term repeatability of PWV, estimated with 6 different devices (Complior Analyse, PulsePen-ETT, PulsePen-ET, SphygmoCor Px/Vx, BPLab, and Mobil-O-Graph), was evaluated in 102 high cardiovascular risk patients hospitalized for suspected coronary artery disease (72 males, 65 ± 13 years). PWV was measured in a single session twice, at 15-minute interval, and its reproducibility was assessed though coefficient of variation (CV), coefficient of repeatability, and intraclass correlation coefficient.RESULTS: The CV of PWV, measured with any of these devices, was <10{\%}. Repeatability was higher with cuff-based methods (BPLab: CV = 5.5{\%} and Mobil-O-Graph: CV = 3.4{\%}) than with devices measuring carotid-femoral PWV (Complior: CV = 8.2{\%}; PulsePen-TT: CV = 8.0{\%}; PulsePen-ETT: CV = 5.8{\%}; and SphygmoCor: CV = 9.5{\%}). In the latter group, PWV repeatability was lower in subjects with higher carotid-femoral PWV. The differences in PWV between repeated measurements, except for the Mobil-O-Graph, did not depend on short-term variations of mean blood pressure or heart rate.CONCLUSIONS: Our study shows that the short-term repeatability of PWV measures is good but not homogenous across different devices and at different PWV values. These findings, obtained in patients at high cardiovascular risk, may be relevant when evaluating the prognostic importance of PWV.",
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T1 - Short-Term Repeatability of Noninvasive Aortic Pulse Wave Velocity Assessment

T2 - Comparison Between Methods and Devices

AU - Grillo, Andrea

AU - Parati, Gianfranco

AU - Rovina, Matteo

AU - Moretti, Francesco

AU - Salvi, Lucia

AU - Gao, Lan

AU - Baldi, Corrado

AU - Sorropago, Giovanni

AU - Faini, Andrea

AU - Millasseau, Sandrine C

AU - Scalise, Filippo

AU - Carretta, Renzo

AU - Salvi, Paolo

PY - 2017/12/8

Y1 - 2017/12/8

N2 - BACKGROUND: Aortic pulse wave velocity (PWV) is an indirect index of arterial stiffness and an independent cardiovascular risk factor. Consistency of PWV assessment over time is thus an essential feature for its clinical application. However, studies providing a comparative estimate of the reproducibility of PWV across different noninvasive devices are lacking, especially in the elderly and in individuals at high cardiovascular risk.METHODS: Aimed at filling this gap, short-term repeatability of PWV, estimated with 6 different devices (Complior Analyse, PulsePen-ETT, PulsePen-ET, SphygmoCor Px/Vx, BPLab, and Mobil-O-Graph), was evaluated in 102 high cardiovascular risk patients hospitalized for suspected coronary artery disease (72 males, 65 ± 13 years). PWV was measured in a single session twice, at 15-minute interval, and its reproducibility was assessed though coefficient of variation (CV), coefficient of repeatability, and intraclass correlation coefficient.RESULTS: The CV of PWV, measured with any of these devices, was <10%. Repeatability was higher with cuff-based methods (BPLab: CV = 5.5% and Mobil-O-Graph: CV = 3.4%) than with devices measuring carotid-femoral PWV (Complior: CV = 8.2%; PulsePen-TT: CV = 8.0%; PulsePen-ETT: CV = 5.8%; and SphygmoCor: CV = 9.5%). In the latter group, PWV repeatability was lower in subjects with higher carotid-femoral PWV. The differences in PWV between repeated measurements, except for the Mobil-O-Graph, did not depend on short-term variations of mean blood pressure or heart rate.CONCLUSIONS: Our study shows that the short-term repeatability of PWV measures is good but not homogenous across different devices and at different PWV values. These findings, obtained in patients at high cardiovascular risk, may be relevant when evaluating the prognostic importance of PWV.

AB - BACKGROUND: Aortic pulse wave velocity (PWV) is an indirect index of arterial stiffness and an independent cardiovascular risk factor. Consistency of PWV assessment over time is thus an essential feature for its clinical application. However, studies providing a comparative estimate of the reproducibility of PWV across different noninvasive devices are lacking, especially in the elderly and in individuals at high cardiovascular risk.METHODS: Aimed at filling this gap, short-term repeatability of PWV, estimated with 6 different devices (Complior Analyse, PulsePen-ETT, PulsePen-ET, SphygmoCor Px/Vx, BPLab, and Mobil-O-Graph), was evaluated in 102 high cardiovascular risk patients hospitalized for suspected coronary artery disease (72 males, 65 ± 13 years). PWV was measured in a single session twice, at 15-minute interval, and its reproducibility was assessed though coefficient of variation (CV), coefficient of repeatability, and intraclass correlation coefficient.RESULTS: The CV of PWV, measured with any of these devices, was <10%. Repeatability was higher with cuff-based methods (BPLab: CV = 5.5% and Mobil-O-Graph: CV = 3.4%) than with devices measuring carotid-femoral PWV (Complior: CV = 8.2%; PulsePen-TT: CV = 8.0%; PulsePen-ETT: CV = 5.8%; and SphygmoCor: CV = 9.5%). In the latter group, PWV repeatability was lower in subjects with higher carotid-femoral PWV. The differences in PWV between repeated measurements, except for the Mobil-O-Graph, did not depend on short-term variations of mean blood pressure or heart rate.CONCLUSIONS: Our study shows that the short-term repeatability of PWV measures is good but not homogenous across different devices and at different PWV values. These findings, obtained in patients at high cardiovascular risk, may be relevant when evaluating the prognostic importance of PWV.

KW - Journal Article

U2 - 10.1093/ajh/hpx140

DO - 10.1093/ajh/hpx140

M3 - Article

VL - 31

SP - 80

EP - 88

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

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