Short-term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β-estradiol stimulation of RNA synthesis

O. Sanfilippo, M. Grazia Daidone, G. Di Fronzo, R. Silvestrini

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5 Citations (Scopus)

Abstract

The stimulation of RNA synthesis induced by estradiol was studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER-cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.

Original languageEnglish
Pages (from-to)2365-2369
Number of pages5
JournalCancer
Volume43
Issue number6
Publication statusPublished - 1979

Fingerprint

Estrogen Receptors
Estradiol
RNA
Breast Neoplasms
Neoplasms
Tamoxifen
Hormones
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Short-term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β-estradiol stimulation of RNA synthesis. / Sanfilippo, O.; Grazia Daidone, M.; Di Fronzo, G.; Silvestrini, R.

In: Cancer, Vol. 43, No. 6, 1979, p. 2365-2369.

Research output: Contribution to journalArticle

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