Abstract
The stimulation of RNA synthesis induced by estradiol was studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER-cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.
| Original language | English |
|---|---|
| Pages (from-to) | 2365-2369 |
| Number of pages | 5 |
| Journal | Cancer |
| Volume | 43 |
| Issue number | 6 |
| Publication status | Published - 1979 |
ASJC Scopus subject areas
- Cancer Research
- Oncology
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Sanfilippo, O., Grazia Daidone, M., Di Fronzo, G., & Silvestrini, R. (1979). Short-term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β-estradiol stimulation of RNA synthesis. Cancer, 43(6), 2365-2369.