Abstract
The stimulation of RNA synthesis induced by estradiol was studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER-cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.
| Original language | English |
|---|---|
| Pages (from-to) | 2365-2369 |
| Number of pages | 5 |
| Journal | Cancer |
| Volume | 43 |
| Issue number | 6 |
| Publication status | Published - 1979 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Short-term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β-estradiol stimulation of RNA synthesis. / Sanfilippo, O.; Grazia Daidone, M.; Di Fronzo, G.; Silvestrini, R.
In: Cancer, Vol. 43, No. 6, 1979, p. 2365-2369.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Short-term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β-estradiol stimulation of RNA synthesis
AU - Sanfilippo, O.
AU - Grazia Daidone, M.
AU - Di Fronzo, G.
AU - Silvestrini, R.
PY - 1979
Y1 - 1979
N2 - The stimulation of RNA synthesis induced by estradiol was studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER-cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.
AB - The stimulation of RNA synthesis induced by estradiol was studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER-cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018646393&partnerID=8YFLogxK
M3 - Article
C2 - 455226
AN - SCOPUS:0018646393
VL - 43
SP - 2365
EP - 2369
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 6
ER -