Short-term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β-estradiol stimulation of RNA synthesis

O. Sanfilippo; M. Grazia Daidone; G. Di Fronzo; R. Silvestrini

Short-term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β-estradiol stimulation of RNA synthesis

O. Sanfilippo, M. Grazia Daidone, G. Di Fronzo, R. Silvestrini

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

The stimulation of RNA synthesis induced by estradiol was studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER⁺ cancers and lower (25%) in ER^-cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.

Original language	English
Pages (from-to)	2365-2369
Number of pages	5
Journal	Cancer
Volume	43
Issue number	6
Publication status	Published - 1979

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

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title = "Short-term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β-estradiol stimulation of RNA synthesis",

abstract = "The stimulation of RNA synthesis induced by estradiol was studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER-cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.",

author = "O. Sanfilippo and {Grazia Daidone}, M. and {Di Fronzo}, G. and R. Silvestrini",

year = "1979",

language = "English",

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journal = "Cancer",

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AU - Sanfilippo, O.

AU - Grazia Daidone, M.

AU - Di Fronzo, G.

AU - Silvestrini, R.

PY - 1979

Y1 - 1979

N2 - The stimulation of RNA synthesis induced by estradiol was studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER-cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.

AB - The stimulation of RNA synthesis induced by estradiol was studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER-cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.

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Short-term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β-estradiol stimulation of RNA synthesis

Abstract

ASJC Scopus subject areas

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