Short-term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β-estradiol stimulation of RNA synthesis

O. Sanfilippo, M. Grazia Daidone, G. Di Fronzo, R. Silvestrini

Research output: Contribution to journalArticle

Abstract

The stimulation of RNA synthesis induced by estradiol was studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER-cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.

Original languageEnglish
Pages (from-to)2365-2369
Number of pages5
JournalCancer
Volume43
Issue number6
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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