Short-term treatment of reflux oesophagitis with ranitidine 300 mg nocte. Italian multicentre study

E. Bovero, R. Cheli, L. Barbara, F. Baldi, A. Boero, G. C. Mura, E. Camarri, P. Corradini, G. Dobrilla, L. Piazzi, M. Dodero, P. Michetti, G. Mazzacca, F. Sabbatini, A. Saggioro, G. Chiozzini, G. Verme, S. Recchia

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A multicentre study involving 9 Italian institutions was carried out to compare the efficacy and safety of ranitidine 150 mg b.i.d. and ranitidine 300 mg nocte in the treatment of reflux oesophagitis. 117 patients with histologically proven oesophagitis were randomly allocated to two comparable treatment groups. Efficacy and reliability were evaluated by clinical and laboratory tests at the beginning of the study, and at 3 and 6 weeks; endoscopy and biopsies were performed at the beginning and at 6 weeks. Treatment with ranitidine for 6 weeks led to total disappearance of gastro-oesophageal reflux symptoms in 60% of patients, with percentages of partial improvement varying between 85% and 95% of cases. Improvement in the results of endoscopic examination was 85%, of which 55% were cured. Microscopic examination revealed an improvement of 36% and 44%, with a cure rate of 18% and 26% respectively. With regard neither to the regression of symptoms nor to the macroscopic and microscopic inflammation of the oesophageal mucosa did statistical examination show significant differences in the therapeutic efficacy of ranitidine 150 mg b.i.d. or 300 mg nocte for treatment of reflux oesophagitis.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalHepato-Gastroenterology
Volume34
Issue number4
Publication statusPublished - 1987

Fingerprint

Peptic Esophagitis
Ranitidine
Multicenter Studies
Therapeutics
Esophagitis
Gastroesophageal Reflux
Endoscopy
Inflammation
Biopsy
Safety

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Bovero, E., Cheli, R., Barbara, L., Baldi, F., Boero, A., Mura, G. C., ... Recchia, S. (1987). Short-term treatment of reflux oesophagitis with ranitidine 300 mg nocte. Italian multicentre study. Hepato-Gastroenterology, 34(4), 155-159.

Short-term treatment of reflux oesophagitis with ranitidine 300 mg nocte. Italian multicentre study. / Bovero, E.; Cheli, R.; Barbara, L.; Baldi, F.; Boero, A.; Mura, G. C.; Camarri, E.; Corradini, P.; Dobrilla, G.; Piazzi, L.; Dodero, M.; Michetti, P.; Mazzacca, G.; Sabbatini, F.; Saggioro, A.; Chiozzini, G.; Verme, G.; Recchia, S.

In: Hepato-Gastroenterology, Vol. 34, No. 4, 1987, p. 155-159.

Research output: Contribution to journalArticle

Bovero, E, Cheli, R, Barbara, L, Baldi, F, Boero, A, Mura, GC, Camarri, E, Corradini, P, Dobrilla, G, Piazzi, L, Dodero, M, Michetti, P, Mazzacca, G, Sabbatini, F, Saggioro, A, Chiozzini, G, Verme, G & Recchia, S 1987, 'Short-term treatment of reflux oesophagitis with ranitidine 300 mg nocte. Italian multicentre study', Hepato-Gastroenterology, vol. 34, no. 4, pp. 155-159.
Bovero E, Cheli R, Barbara L, Baldi F, Boero A, Mura GC et al. Short-term treatment of reflux oesophagitis with ranitidine 300 mg nocte. Italian multicentre study. Hepato-Gastroenterology. 1987;34(4):155-159.
Bovero, E. ; Cheli, R. ; Barbara, L. ; Baldi, F. ; Boero, A. ; Mura, G. C. ; Camarri, E. ; Corradini, P. ; Dobrilla, G. ; Piazzi, L. ; Dodero, M. ; Michetti, P. ; Mazzacca, G. ; Sabbatini, F. ; Saggioro, A. ; Chiozzini, G. ; Verme, G. ; Recchia, S. / Short-term treatment of reflux oesophagitis with ranitidine 300 mg nocte. Italian multicentre study. In: Hepato-Gastroenterology. 1987 ; Vol. 34, No. 4. pp. 155-159.
@article{738cf41ad7fd4820b963eb2b5e0f6250,
title = "Short-term treatment of reflux oesophagitis with ranitidine 300 mg nocte. Italian multicentre study",
abstract = "A multicentre study involving 9 Italian institutions was carried out to compare the efficacy and safety of ranitidine 150 mg b.i.d. and ranitidine 300 mg nocte in the treatment of reflux oesophagitis. 117 patients with histologically proven oesophagitis were randomly allocated to two comparable treatment groups. Efficacy and reliability were evaluated by clinical and laboratory tests at the beginning of the study, and at 3 and 6 weeks; endoscopy and biopsies were performed at the beginning and at 6 weeks. Treatment with ranitidine for 6 weeks led to total disappearance of gastro-oesophageal reflux symptoms in 60{\%} of patients, with percentages of partial improvement varying between 85{\%} and 95{\%} of cases. Improvement in the results of endoscopic examination was 85{\%}, of which 55{\%} were cured. Microscopic examination revealed an improvement of 36{\%} and 44{\%}, with a cure rate of 18{\%} and 26{\%} respectively. With regard neither to the regression of symptoms nor to the macroscopic and microscopic inflammation of the oesophageal mucosa did statistical examination show significant differences in the therapeutic efficacy of ranitidine 150 mg b.i.d. or 300 mg nocte for treatment of reflux oesophagitis.",
author = "E. Bovero and R. Cheli and L. Barbara and F. Baldi and A. Boero and Mura, {G. C.} and E. Camarri and P. Corradini and G. Dobrilla and L. Piazzi and M. Dodero and P. Michetti and G. Mazzacca and F. Sabbatini and A. Saggioro and G. Chiozzini and G. Verme and S. Recchia",
year = "1987",
language = "English",
volume = "34",
pages = "155--159",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "4",

}

TY - JOUR

T1 - Short-term treatment of reflux oesophagitis with ranitidine 300 mg nocte. Italian multicentre study

AU - Bovero, E.

AU - Cheli, R.

AU - Barbara, L.

AU - Baldi, F.

AU - Boero, A.

AU - Mura, G. C.

AU - Camarri, E.

AU - Corradini, P.

AU - Dobrilla, G.

AU - Piazzi, L.

AU - Dodero, M.

AU - Michetti, P.

AU - Mazzacca, G.

AU - Sabbatini, F.

AU - Saggioro, A.

AU - Chiozzini, G.

AU - Verme, G.

AU - Recchia, S.

PY - 1987

Y1 - 1987

N2 - A multicentre study involving 9 Italian institutions was carried out to compare the efficacy and safety of ranitidine 150 mg b.i.d. and ranitidine 300 mg nocte in the treatment of reflux oesophagitis. 117 patients with histologically proven oesophagitis were randomly allocated to two comparable treatment groups. Efficacy and reliability were evaluated by clinical and laboratory tests at the beginning of the study, and at 3 and 6 weeks; endoscopy and biopsies were performed at the beginning and at 6 weeks. Treatment with ranitidine for 6 weeks led to total disappearance of gastro-oesophageal reflux symptoms in 60% of patients, with percentages of partial improvement varying between 85% and 95% of cases. Improvement in the results of endoscopic examination was 85%, of which 55% were cured. Microscopic examination revealed an improvement of 36% and 44%, with a cure rate of 18% and 26% respectively. With regard neither to the regression of symptoms nor to the macroscopic and microscopic inflammation of the oesophageal mucosa did statistical examination show significant differences in the therapeutic efficacy of ranitidine 150 mg b.i.d. or 300 mg nocte for treatment of reflux oesophagitis.

AB - A multicentre study involving 9 Italian institutions was carried out to compare the efficacy and safety of ranitidine 150 mg b.i.d. and ranitidine 300 mg nocte in the treatment of reflux oesophagitis. 117 patients with histologically proven oesophagitis were randomly allocated to two comparable treatment groups. Efficacy and reliability were evaluated by clinical and laboratory tests at the beginning of the study, and at 3 and 6 weeks; endoscopy and biopsies were performed at the beginning and at 6 weeks. Treatment with ranitidine for 6 weeks led to total disappearance of gastro-oesophageal reflux symptoms in 60% of patients, with percentages of partial improvement varying between 85% and 95% of cases. Improvement in the results of endoscopic examination was 85%, of which 55% were cured. Microscopic examination revealed an improvement of 36% and 44%, with a cure rate of 18% and 26% respectively. With regard neither to the regression of symptoms nor to the macroscopic and microscopic inflammation of the oesophageal mucosa did statistical examination show significant differences in the therapeutic efficacy of ranitidine 150 mg b.i.d. or 300 mg nocte for treatment of reflux oesophagitis.

UR - http://www.scopus.com/inward/record.url?scp=0023201028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023201028&partnerID=8YFLogxK

M3 - Article

VL - 34

SP - 155

EP - 159

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 4

ER -