Short term variation in NTproBNP after lifestyle intervention in severe obesity

Debora Fedele, Virginia Bicchiega, Alessandro Collo, Federica Barutta, Erika Pistone, Gabriella Gruden, Graziella Bruno

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim Natriuretic peptides are not only involved in cardiovascular adaption to various conditions, but also in metabolic diseases. We performed this study to assess the effect of a very short time of lifestyle inpatient intervention on NTproBNP values in normotensive subjects with severe obesity and normal cardiac function. Methods We recruited 14 consecutive obese normotensive subjects with normal cardiac function who were aged 30 years and more and were referred to inpatient rehabilitation in an academic clinic over a two months period. They were examined at baseline and after a 3-weeks program including dietary intervention with hypocaloric diet and assisted personalized physical aerobic and anaerobic activities and compared to age, sex and BMI-matched control subjects under usual care. Results BMI significantly decreased (40.8 ±1.6 vs 42.3 ± 1.6 kg/m2, p <0.0001). Median reduction in body weight was 4.9 kg (interquartile range 2.4-5.2 kg). After diet and exercise-induced weight loss, plasma NTproBNP levels showed an almost two-fold increase, which was statistically significant (28.2 ± 12.3 vs 17.2 ± 13.2 ng/L, p = 0.01), and particularly relevant in the subgroup with NT-proBNP values below median values compared to those with higher values (p = 0.02). No significant variations were found in control subjects (18.0 ± 13.0 vs 16.5 ± 11.2 ng/L, p = 0.18). The lipid profile was significantly ameliorated, and both HbA1c and insulin levels showed a marginally non-significant decrease after treatment. Conclusions An almost two-fold increase in NTproBNP levels was evident after a very short time period of lifestyle intervention in normotensive severe obese patients without cardiac disease. This finding might have clinical relevance, considering the role of NT-proBNP as risk factor of impaired glucose tolerance.

Original languageEnglish
Article numbere0181212
JournalPLoS One
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

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Morbid Obesity
lifestyle
Life Style
obesity
cardiac output
natriuretic peptides
Nutrition
glycohemoglobin
low calorie diet
metabolic diseases
heart diseases
glucose tolerance
Inpatients
Diet
exercise
insulin
risk factors
weight loss
Natriuretic Peptides
Glucose Intolerance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Fedele, D., Bicchiega, V., Collo, A., Barutta, F., Pistone, E., Gruden, G., & Bruno, G. (2017). Short term variation in NTproBNP after lifestyle intervention in severe obesity. PLoS One, 12(7), [e0181212]. https://doi.org/10.1371/journal.pone.0181212

Short term variation in NTproBNP after lifestyle intervention in severe obesity. / Fedele, Debora; Bicchiega, Virginia; Collo, Alessandro; Barutta, Federica; Pistone, Erika; Gruden, Gabriella; Bruno, Graziella.

In: PLoS One, Vol. 12, No. 7, e0181212, 01.07.2017.

Research output: Contribution to journalArticle

Fedele, D, Bicchiega, V, Collo, A, Barutta, F, Pistone, E, Gruden, G & Bruno, G 2017, 'Short term variation in NTproBNP after lifestyle intervention in severe obesity', PLoS One, vol. 12, no. 7, e0181212. https://doi.org/10.1371/journal.pone.0181212
Fedele, Debora ; Bicchiega, Virginia ; Collo, Alessandro ; Barutta, Federica ; Pistone, Erika ; Gruden, Gabriella ; Bruno, Graziella. / Short term variation in NTproBNP after lifestyle intervention in severe obesity. In: PLoS One. 2017 ; Vol. 12, No. 7.
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AB - Aim Natriuretic peptides are not only involved in cardiovascular adaption to various conditions, but also in metabolic diseases. We performed this study to assess the effect of a very short time of lifestyle inpatient intervention on NTproBNP values in normotensive subjects with severe obesity and normal cardiac function. Methods We recruited 14 consecutive obese normotensive subjects with normal cardiac function who were aged 30 years and more and were referred to inpatient rehabilitation in an academic clinic over a two months period. They were examined at baseline and after a 3-weeks program including dietary intervention with hypocaloric diet and assisted personalized physical aerobic and anaerobic activities and compared to age, sex and BMI-matched control subjects under usual care. Results BMI significantly decreased (40.8 ±1.6 vs 42.3 ± 1.6 kg/m2, p <0.0001). Median reduction in body weight was 4.9 kg (interquartile range 2.4-5.2 kg). After diet and exercise-induced weight loss, plasma NTproBNP levels showed an almost two-fold increase, which was statistically significant (28.2 ± 12.3 vs 17.2 ± 13.2 ng/L, p = 0.01), and particularly relevant in the subgroup with NT-proBNP values below median values compared to those with higher values (p = 0.02). No significant variations were found in control subjects (18.0 ± 13.0 vs 16.5 ± 11.2 ng/L, p = 0.18). The lipid profile was significantly ameliorated, and both HbA1c and insulin levels showed a marginally non-significant decrease after treatment. Conclusions An almost two-fold increase in NTproBNP levels was evident after a very short time period of lifestyle intervention in normotensive severe obese patients without cardiac disease. This finding might have clinical relevance, considering the role of NT-proBNP as risk factor of impaired glucose tolerance.

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