Short-term weekly neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer

G. Porzio, C. Ficorella, G. Toro, I. Paris, E. Ricevuto, P. Marchetti

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty patients with locally advanced cervical cancer (FIGO stage Ib-IIa "bulky"/IIb) were treated with three courses of weekly PVB (day 1: cisplatin, 50 mg/m2; vincristin, 1 mg/m2; bleomycin, 30 IU over 24-hr) in a neoadjuvant setting. Toxicity was generally mild (no grade 3-4 toxicity was observed), and the treatment was well tolerated without reduction of programmed dose intensity. Fourteen patients (70%) experienced a clinical response and underwent surgery within 20 days after the third course of chemotherapy. Six patients (30%) with stable disease were treated with salvage radiotherapy. Two of the 14 responders experienced a pathologic complete response (14.2%); microscopic disease was detected in one patient with clinical complete response. Pelvic node metastases were found in 4/14 patients (28.5%) and microscopic parametrium involvement in 3/14 (21.4%). All 14 patients had free margins of resection. A short-term weekly platinum-based chemotherapy is highly effective, has little toxicity, and allows a prompt salvage therapy for nonresponding patients.

Original languageEnglish
Pages (from-to)25-26
Number of pages2
JournalTumori
Volume87
Issue number1
Publication statusPublished - 2001

Keywords

  • Cervical cancer
  • Neoadjuvant chemotherapy
  • Weekly schedule

ASJC Scopus subject areas

  • Cancer Research

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