Abstract
Ten fetuses with hydronephrosis underwent one to seven urine sampling procedures at 23 to 36 weeks' gestation to evaluate renal function. Postnatally, the infants' renal function was assessed by a combination of serum creatinine measurement, ultrasonography, and renal scintigraphy. Six infants had pyelo-ureteric junction obstruction, two had megabladder with megaureter, and two had vesico-ureteric reflux. All infants had normal serum creatinine levels at the time of postnatal follow-up, but five of the seven with unilateral involvement had moderate or severe renal damage. Abnormal urinary electrolyte concentrations were found antenatally in only two of them. For the three infants with bilateral hydronephrosis, postnatal evaluation showed moderately or severely damaged kidneys despite prenatal evidence of normal biochemical indexes. Fetal urine electrolyte measurement may be accurate in the diagnosis of renal dysplasia, but its sensitivity is poor in predicting moderate renal dysfunction.
| Original language | English |
|---|---|
| Pages (from-to) | 1401-1404 |
| Number of pages | 4 |
| Journal | Journal of Pediatric Surgery |
| Volume | 31 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1996 |
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Keywords
- fetal urine biochemistry
- Hydronephrosis
- prenatal diagnosis
- renal function
ASJC Scopus subject areas
- Surgery
Cite this
Shortcomings in predicting postnatal renal function using prenatal urine biochemistry in fetuses with congenital hydronephrosis. / Guez, Sophie; Assael, Baroukh Maurice; Melzi, Maria Luisa; Tassis, Beatrice; Nicolini, Umberto.
In: Journal of Pediatric Surgery, Vol. 31, No. 10, 10.1996, p. 1401-1404.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Shortcomings in predicting postnatal renal function using prenatal urine biochemistry in fetuses with congenital hydronephrosis
AU - Guez, Sophie
AU - Assael, Baroukh Maurice
AU - Melzi, Maria Luisa
AU - Tassis, Beatrice
AU - Nicolini, Umberto
PY - 1996/10
Y1 - 1996/10
N2 - Ten fetuses with hydronephrosis underwent one to seven urine sampling procedures at 23 to 36 weeks' gestation to evaluate renal function. Postnatally, the infants' renal function was assessed by a combination of serum creatinine measurement, ultrasonography, and renal scintigraphy. Six infants had pyelo-ureteric junction obstruction, two had megabladder with megaureter, and two had vesico-ureteric reflux. All infants had normal serum creatinine levels at the time of postnatal follow-up, but five of the seven with unilateral involvement had moderate or severe renal damage. Abnormal urinary electrolyte concentrations were found antenatally in only two of them. For the three infants with bilateral hydronephrosis, postnatal evaluation showed moderately or severely damaged kidneys despite prenatal evidence of normal biochemical indexes. Fetal urine electrolyte measurement may be accurate in the diagnosis of renal dysplasia, but its sensitivity is poor in predicting moderate renal dysfunction.
AB - Ten fetuses with hydronephrosis underwent one to seven urine sampling procedures at 23 to 36 weeks' gestation to evaluate renal function. Postnatally, the infants' renal function was assessed by a combination of serum creatinine measurement, ultrasonography, and renal scintigraphy. Six infants had pyelo-ureteric junction obstruction, two had megabladder with megaureter, and two had vesico-ureteric reflux. All infants had normal serum creatinine levels at the time of postnatal follow-up, but five of the seven with unilateral involvement had moderate or severe renal damage. Abnormal urinary electrolyte concentrations were found antenatally in only two of them. For the three infants with bilateral hydronephrosis, postnatal evaluation showed moderately or severely damaged kidneys despite prenatal evidence of normal biochemical indexes. Fetal urine electrolyte measurement may be accurate in the diagnosis of renal dysplasia, but its sensitivity is poor in predicting moderate renal dysfunction.
KW - fetal urine biochemistry
KW - Hydronephrosis
KW - prenatal diagnosis
KW - renal function
UR - http://www.scopus.com/inward/record.url?scp=0029908480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029908480&partnerID=8YFLogxK
U2 - 10.1016/S0022-3468(96)90838-6
DO - 10.1016/S0022-3468(96)90838-6
M3 - Article
C2 - 8906671
AN - SCOPUS:0029908480
VL - 31
SP - 1401
EP - 1404
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
SN - 0022-3468
IS - 10
ER -