Shortened time to recovery from chemotherapy induced neutropenia in pediatric patients with high dose combined cytokines

Giovanni Deb, Alberto Donfrancesco, Luigi De Sio, Raffaele Cozza, Aurora Castellano, Fidan Paole, Lawrence Helson

Research output: Contribution to journalArticle

Abstract

Granulocyte colony stimulating factor (G-CSF) and granulocyte macrophage colony stimulating factor (GM-CSF) are cytokines which have been extensively administered as monotherapy to patients with a variety of hematopoietic disorders at dosages of 5 mcg/kg/day. Because their spectrum of activity is both singular and simultaneously overlapping, we postulated that combined therapy would be more advantageous than monotherapy. Since 1992 we have carried out a study of G-CSF and GM-CSF as monotherapy or in combination in pediatric patients with solid tumors following chemotherapy induced nadirs of 0-800 WBC/mm3. When combined, the cytokines were given twice per day at 2.5 or 5.0 mcg/kg. For the monotherapy groups, either cytokine at 5 mcg/kg or 10 mcg/kg was given once daily. The mean time to recovery from neutropenia nadir ranged from 6.6-8.2 days in patients receiving a total of 10 mcg/kg/day compared to 10.4-10.6 days in patients treated with 5 mcg/kg/day. Side effects were ephemeral eosinophilia. The dosage of 10 mcg/kg/day appears to be a better dosage for pediatric patients with a slight advantage in the combined twice a day schedule (6.6 days).

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalAnticancer Research
Volume18
Issue number1 B
Publication statusPublished - Jan 1998

Keywords

  • Chemotherapy
  • Cytokines
  • Neutropenia
  • Pediatric patients

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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