Abstract
The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3' A/3'A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4+ T cell counts + T cells + T lymphocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 311-315 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 182 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2000 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
Cite this
Shorter survival of SDF1-3' A/3' A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection. / Brambilla, Andrea; Villa, Chiara; Rizzardi, GianPaolo; Veglia, Fabrizio; Ghezzi, Silvia; Lazzarin, Adriano; Cusini, Marco; Muratori, Simona; Santagostino, Elena; Gringeri, Alessandro; Louie, Leslie G.; Sheppard, Haynes W.; Poli, Guido; Michael, Nelson L.; Pantaleo, Giuseppe; Vicenzi, Elisa.
In: Journal of Infectious Diseases, Vol. 182, No. 1, 2000, p. 311-315.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Shorter survival of SDF1-3' A/3' A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection
AU - Brambilla, Andrea
AU - Villa, Chiara
AU - Rizzardi, GianPaolo
AU - Veglia, Fabrizio
AU - Ghezzi, Silvia
AU - Lazzarin, Adriano
AU - Cusini, Marco
AU - Muratori, Simona
AU - Santagostino, Elena
AU - Gringeri, Alessandro
AU - Louie, Leslie G.
AU - Sheppard, Haynes W.
AU - Poli, Guido
AU - Michael, Nelson L.
AU - Pantaleo, Giuseppe
AU - Vicenzi, Elisa
PY - 2000
Y1 - 2000
N2 - The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3' A/3'A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4+ T cell counts + T cells + T lymphocytes.
AB - The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3' A/3'A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4+ T cell counts + T cells + T lymphocytes.
UR - http://www.scopus.com/inward/record.url?scp=0033930343&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033930343&partnerID=8YFLogxK
U2 - 10.1086/315650
DO - 10.1086/315650
M3 - Article
C2 - 10882614
AN - SCOPUS:0033930343
VL - 182
SP - 311
EP - 315
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -