Shorter survival of SDF1-3' A/3' A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection

Andrea Brambilla, Chiara Villa, GianPaolo Rizzardi, Fabrizio Veglia, Silvia Ghezzi, Adriano Lazzarin, Marco Cusini, Simona Muratori, Elena Santagostino, Alessandro Gringeri, Leslie G. Louie, Haynes W. Sheppard, Guido Poli, Nelson L. Michael, Giuseppe Pantaleo, Elisa Vicenzi

Research output: Contribution to journalArticlepeer-review

Abstract

The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3' A/3'A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4+ T cell counts + T cells + T lymphocytes.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalJournal of Infectious Diseases
Volume182
Issue number1
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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