Abstract
The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3' A/3'A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4+ T cell counts + T cells + T lymphocytes.
Original language | English |
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Pages (from-to) | 311-315 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 182 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2000 |
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology