Shorter survival of SDF1-3' A/3' A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection

Andrea Brambilla; Chiara Villa; GianPaolo Rizzardi; Fabrizio Veglia; Silvia Ghezzi; Adriano Lazzarin; Marco Cusini; Simona Muratori; Elena Santagostino; Alessandro Gringeri; Leslie G. Louie; Haynes W. Sheppard; Guido Poli; Nelson L. Michael; Giuseppe Pantaleo; Elisa Vicenzi

doi:10.1086/315650

Shorter survival of SDF1-3' A/3' A homozygotes linked to CD4⁺ T cell decrease in advanced human immunodeficiency virus type 1 infection

Andrea Brambilla, Chiara Villa, GianPaolo Rizzardi, Fabrizio Veglia, Silvia Ghezzi, Adriano Lazzarin, Marco Cusini, Simona Muratori, Elena Santagostino, Alessandro Gringeri, Leslie G. Louie, Haynes W. Sheppard, Guido Poli, Nelson L. Michael, Giuseppe Pantaleo, Elisa Vicenzi

Research output: Contribution to journal › Article › peer-review

Abstract

The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3' A/3'A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4⁺ T cell counts + T cells + T lymphocytes.

Original language	English
Pages (from-to)	311-315
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	182
Issue number	1
DOIs	https://doi.org/10.1086/315650
Publication status	Published - 2000

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Immunology

Access to Document

10.1086/315650

Cite this

Brambilla, A., Villa, C., Rizzardi, G., Veglia, F., Ghezzi, S., Lazzarin, A., Cusini, M., Muratori, S., Santagostino, E., Gringeri, A., Louie, L. G., Sheppard, H. W., Poli, G., Michael, N. L., Pantaleo, G., & Vicenzi, E. (2000). Shorter survival of SDF1-3' A/3' A homozygotes linked to CD4⁺ T cell decrease in advanced human immunodeficiency virus type 1 infection. Journal of Infectious Diseases, 182(1), 311-315. https://doi.org/10.1086/315650

Brambilla, A, Villa, C, Rizzardi, G, Veglia, F, Ghezzi, S, Lazzarin, A, Cusini, M , Muratori, S , Santagostino, E, Gringeri, A, Louie, LG, Sheppard, HW, Poli, G, Michael, NL, Pantaleo, G & Vicenzi, E 2000, 'Shorter survival of SDF1-3' A/3' A homozygotes linked to CD4⁺ T cell decrease in advanced human immunodeficiency virus type 1 infection', Journal of Infectious Diseases, vol. 182, no. 1, pp. 311-315. https://doi.org/10.1086/315650

@article{5d9d8fcf6a1f4f0396f32949bf8cf433,

title = "Shorter survival of SDF1-3' A/3' A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection",

abstract = "The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3' A/3'A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4+ T cell counts + T cells + T lymphocytes.",

author = "Andrea Brambilla and Chiara Villa and GianPaolo Rizzardi and Fabrizio Veglia and Silvia Ghezzi and Adriano Lazzarin and Marco Cusini and Simona Muratori and Elena Santagostino and Alessandro Gringeri and Louie, {Leslie G.} and Sheppard, {Haynes W.} and Guido Poli and Michael, {Nelson L.} and Giuseppe Pantaleo and Elisa Vicenzi",

year = "2000",

doi = "10.1086/315650",

language = "English",

volume = "182",

pages = "311--315",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Shorter survival of SDF1-3' A/3' A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection

AU - Brambilla, Andrea

AU - Villa, Chiara

AU - Rizzardi, GianPaolo

AU - Veglia, Fabrizio

AU - Ghezzi, Silvia

AU - Lazzarin, Adriano

AU - Cusini, Marco

AU - Muratori, Simona

AU - Santagostino, Elena

AU - Gringeri, Alessandro

AU - Louie, Leslie G.

AU - Sheppard, Haynes W.

AU - Poli, Guido

AU - Michael, Nelson L.

AU - Pantaleo, Giuseppe

AU - Vicenzi, Elisa

PY - 2000

Y1 - 2000

N2 - The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3' A/3'A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4+ T cell counts + T cells + T lymphocytes.

AB - The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3' A/3'A genotype and accelerated disease progression was evident among seroconverters (n = 319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4+ T cell counts + T cells + T lymphocytes.

UR - http://www.scopus.com/inward/record.url?scp=0033930343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033930343&partnerID=8YFLogxK

U2 - 10.1086/315650

DO - 10.1086/315650

M3 - Article

C2 - 10882614

AN - SCOPUS:0033930343

VL - 182

SP - 311

EP - 315

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -

Shorter survival of SDF1-3' A/3' A homozygotes linked to CD4⁺ T cell decrease in advanced human immunodeficiency virus type 1 infection

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this