Should a renal biopsy be performed at the first relapse of 'clinical nephrotic syndrome'?

Pietro Ferrara, Antonio Mastrangelo, Alessandro Nicoletti, Antonio Gatto, Valerio Gaetano Vellone, Gianfranco Zannoni

Research output: Contribution to journalArticlepeer-review


Immunoglobulin A (IgA) nephropathy is considered to be the commonest primary glomerulonephritis worldwide. The commonest clinical presentation of the disease is macroscopic hematuria, and nephrotic syndrome (NS) at the time of onset of symptoms is a predictor of poor outcome in both adults and children. In this report we describe a case of IgA nephropathy in a 15-year-old girl with a diagnosis of NS who was admitted to our hospital following 15 days of remarkable weight gain, and eyelid and pretibial oedema. NS was diagnosed when she was 3 years old. During the period between diagnosis and our observation the patient presented with three episodes of relapse. After the third episode a renal biopsy was performed and, together with clinical data, this enabled us to make the diagnosis of IgA nephropathy. NS is now recognized as a possible clinical manifestation of an IgA nephropathy, even at onset. Based on this case report, we suggest that a more vigilant management of children with NS may be necessary, even if they do not have atypical characteristics at onset. We suggest that it may be better to perform a renal biopsy at the time of first relapse.

Original languageEnglish
Pages (from-to)184-186
Number of pages3
JournalScandinavian Journal of Urology and Nephrology
Issue number2
Publication statusPublished - 2008


  • Immunoglobulin A nephropathy
  • Nephrotic syndrome
  • Renal biopsy

ASJC Scopus subject areas

  • Nephrology
  • Urology


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