Shunt-associated migraine responds favorably to atrial septal repair: A case-control study

Gian P. Anzola, Giovanni B. Frisoni, Eva Morandi, Francesco Casilli, Eustaquio Onorato

Research output: Contribution to journalArticlepeer-review


Background and Purpose - Transcatheter closure of patent foramen ovale (PFO) has been reported to improve migraine in patients with cerebrovascular disorders in noncontrolled studies. The aim of the study was to compare the course of migraine assessed prospectively over a 12-month period in symptomatic (for cerebrovascular disease) and asymptomatic patients undergoing PFO closure and in patients with PFO treated medically. Methods - Twenty-three stroke symptomatic (SS; 39±10 years of age; males/females [M/F] 5/18) and 27 stroke asymptomatic (SA; 40±12 years of age; M/F 5/22) patients with migraine underwent PFO closure. Twenty-seven patients with migraine and PFO (controls [CTRLS]; 36±11 years of age; M/F 4/23) were followed up medically. Migraine severity was assessed at baseline with a scale that takes into account the frequency, duration, and intensity of the attacks and the occurrence of aura (score range 0 to 10). Six months later, the patients were given a structured diary to annotate monthly with the same scale the characteristics of the attacks for the next 6 months. By the end of 1 year, the migraine score was averaged for the last 6 months. Results - Baseline severity of migraine did not differ between groups (6.3 to 6.1 and 6.7 in SS, SA, and CTRLS groups, respectively). At the 1-year assessment, the overall migraine score had significantly improved by 3.7 and 2.8 points in SS and SA, respectively (P

Original languageEnglish
Pages (from-to)430-434
Number of pages5
Issue number2
Publication statusPublished - Feb 2006


  • Foramen ovale, patent
  • Migraine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)


Dive into the research topics of 'Shunt-associated migraine responds favorably to atrial septal repair: A case-control study'. Together they form a unique fingerprint.

Cite this