Abstract
Glucose and the acetylcholinesterase inhibitor tacrine were tested, alone and in combination, in mice of the CD-1 strain subjected to five daily shuttle-box training sessions. Pretraining intraperitoneal administration of glucose alone (50-400 mg/kg) had no significant effect, while tacrine alone (0.5-3 mg/kg) improved avoidance acquisition at the dose of 2 mg/kg only. Significant avoidance learning improvements were instead produced by 50 or 100 mg/kg glucose combined with 0.5 or 1 mg/kg tacrine. The effects on shuttle-box avoidance acquisition produced by glucose combined with a cholinomimetic agent support the hypothesis that cholinergic mechanisms may be involved in the action of glucose on learning and memory. However, the main finding of the present study is related to the enhancement by glucose of the learning improving action of a drug clinically used as cognitive enhancer.
| Original language | English |
|---|---|
| Pages (from-to) | 204-210 |
| Number of pages | 7 |
| Journal | Neurobiology of Learning and Memory |
| Volume | 69 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 1998 |
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Keywords
- Active avoidance
- Glucose
- Learning improvement by drug combination
- Mice
- Tacrine
ASJC Scopus subject areas
- Behavioral Neuroscience
- Cognitive Neuroscience
- Experimental and Cognitive Psychology
Cite this
Shuttle-box avoidance learning in mice : Improvement by combined glucose and tacrine. / Pavone, Flaminia; Capone, Francesca; Battaglia, Mario; Sansone, Mario.
In: Neurobiology of Learning and Memory, Vol. 69, No. 2, 03.1998, p. 204-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Shuttle-box avoidance learning in mice
T2 - Improvement by combined glucose and tacrine
AU - Pavone, Flaminia
AU - Capone, Francesca
AU - Battaglia, Mario
AU - Sansone, Mario
PY - 1998/3
Y1 - 1998/3
N2 - Glucose and the acetylcholinesterase inhibitor tacrine were tested, alone and in combination, in mice of the CD-1 strain subjected to five daily shuttle-box training sessions. Pretraining intraperitoneal administration of glucose alone (50-400 mg/kg) had no significant effect, while tacrine alone (0.5-3 mg/kg) improved avoidance acquisition at the dose of 2 mg/kg only. Significant avoidance learning improvements were instead produced by 50 or 100 mg/kg glucose combined with 0.5 or 1 mg/kg tacrine. The effects on shuttle-box avoidance acquisition produced by glucose combined with a cholinomimetic agent support the hypothesis that cholinergic mechanisms may be involved in the action of glucose on learning and memory. However, the main finding of the present study is related to the enhancement by glucose of the learning improving action of a drug clinically used as cognitive enhancer.
AB - Glucose and the acetylcholinesterase inhibitor tacrine were tested, alone and in combination, in mice of the CD-1 strain subjected to five daily shuttle-box training sessions. Pretraining intraperitoneal administration of glucose alone (50-400 mg/kg) had no significant effect, while tacrine alone (0.5-3 mg/kg) improved avoidance acquisition at the dose of 2 mg/kg only. Significant avoidance learning improvements were instead produced by 50 or 100 mg/kg glucose combined with 0.5 or 1 mg/kg tacrine. The effects on shuttle-box avoidance acquisition produced by glucose combined with a cholinomimetic agent support the hypothesis that cholinergic mechanisms may be involved in the action of glucose on learning and memory. However, the main finding of the present study is related to the enhancement by glucose of the learning improving action of a drug clinically used as cognitive enhancer.
KW - Active avoidance
KW - Glucose
KW - Learning improvement by drug combination
KW - Mice
KW - Tacrine
UR - http://www.scopus.com/inward/record.url?scp=0031950484&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031950484&partnerID=8YFLogxK
U2 - 10.1006/nlme.1997.3808
DO - 10.1006/nlme.1997.3808
M3 - Article
C2 - 9619996
AN - SCOPUS:0031950484
VL - 69
SP - 204
EP - 210
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
SN - 1074-7427
IS - 2
ER -