Shuttle-box avoidance learning in mice: Improvement by combined glucose and tacrine

Flaminia Pavone, Francesca Capone, Mario Battaglia, Mario Sansone

Research output: Contribution to journalArticlepeer-review


Glucose and the acetylcholinesterase inhibitor tacrine were tested, alone and in combination, in mice of the CD-1 strain subjected to five daily shuttle-box training sessions. Pretraining intraperitoneal administration of glucose alone (50-400 mg/kg) had no significant effect, while tacrine alone (0.5-3 mg/kg) improved avoidance acquisition at the dose of 2 mg/kg only. Significant avoidance learning improvements were instead produced by 50 or 100 mg/kg glucose combined with 0.5 or 1 mg/kg tacrine. The effects on shuttle-box avoidance acquisition produced by glucose combined with a cholinomimetic agent support the hypothesis that cholinergic mechanisms may be involved in the action of glucose on learning and memory. However, the main finding of the present study is related to the enhancement by glucose of the learning improving action of a drug clinically used as cognitive enhancer.

Original languageEnglish
Pages (from-to)204-210
Number of pages7
JournalNeurobiology of Learning and Memory
Issue number2
Publication statusPublished - Mar 1998


  • Active avoidance
  • Glucose
  • Learning improvement by drug combination
  • Mice
  • Tacrine

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology


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