Shuttle-box avoidance learning in mice: Improvement by glucose combined with stimulant drugs

Mario Sansone, Mario Battaglia, Flaminia Pavone

Research output: Contribution to journalArticlepeer-review

Abstract

Glucose was tested alone or in combination with two stimulant drugs, amphetamine and nicotine, in mice of the CD-1 strain subjected to five daily shuttle-box training sessions. Pretraining intraperitoneal administration of glucose (50 or 100 mg/kg) had no effect, while amphetamine and nicotine, given alone, significantly improved avoidance acquisition at a dose of 0.5 mg/kg, but not 0.025 mg/kg. Significant improvement of avoidance learning was also produced by a combination of glucose with the lower dose of amphetamine or nicotine. This enhancing action, produced by a combination of glucose and stimulant drugs, at doses ineffective by themselves, might be due to a concomitant cholinergic and dopaminergic activation, induced by glucose and stimulant drugs, respectively. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalNeurobiology of Learning and Memory
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 2000

Keywords

  • Active avoidance
  • Amphetamine
  • Glucose
  • Learning improvement by drug combination
  • Mice
  • Nicotine

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

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