Abstract
Glucose was tested alone or in combination with two stimulant drugs, amphetamine and nicotine, in mice of the CD-1 strain subjected to five daily shuttle-box training sessions. Pretraining intraperitoneal administration of glucose (50 or 100 mg/kg) had no effect, while amphetamine and nicotine, given alone, significantly improved avoidance acquisition at a dose of 0.5 mg/kg, but not 0.025 mg/kg. Significant improvement of avoidance learning was also produced by a combination of glucose with the lower dose of amphetamine or nicotine. This enhancing action, produced by a combination of glucose and stimulant drugs, at doses ineffective by themselves, might be due to a concomitant cholinergic and dopaminergic activation, induced by glucose and stimulant drugs, respectively. (C) 2000 Academic Press.
Original language | English |
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Pages (from-to) | 94-100 |
Number of pages | 7 |
Journal | Neurobiology of Learning and Memory |
Volume | 73 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2000 |
Keywords
- Active avoidance
- Amphetamine
- Glucose
- Learning improvement by drug combination
- Mice
- Nicotine
ASJC Scopus subject areas
- Behavioral Neuroscience
- Cognitive Neuroscience
- Experimental and Cognitive Psychology