SIAIP position paper: Provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children 11 Medical and Health Sciences 1115 Pharmacology and Pharmaceutical Sciences

Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi, Francesca Saretta, Gianluigi Marseglia, Marzia Duse, Francesco Paravati

Research output: Contribution to journalArticle

Abstract

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), that aims of ascertaining the causative role of an allergen and evaluating the tolerance to the suspected drug. Different protocols through the administration of divided increasing doses have been postulated according to the type of drug and the onset of the reaction (immediate or non immediate reactions). DPT protocols differ in doses and time interval between doses. In this position paper, the Italian Pediatric Society for Allergy and Immunology provides a practical guide for provocation test to antibiotics and NSAIDs in children and adolescents.

Original languageEnglish
Article number147
JournalItalian Journal of Pediatrics
Volume44
Issue number1
DOIs
Publication statusPublished - Dec 7 2018

Keywords

  • Allergy
  • Antibiotics
  • Challenge
  • Children
  • Diagnosis
  • Drug allergy
  • Drug hypersensitivity reactions
  • Non-steroidal anti-inflammatory drugs
  • Pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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  • Cite this

    Caffarelli, C., Franceschini, F., Caimmi, D., Mori, F., Diaferio, L., Di Mauro, D., Mastrorilli, C., Arasi, S., Barni, S., Bottau, P., Caimmi, S., Cardinale, F., Comberiati, P., Crisafulli, G., Liotti, L., Pelosi, U., Saretta, F., Marseglia, G., Duse, M., & Paravati, F. (2018). SIAIP position paper: Provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children 11 Medical and Health Sciences 1115 Pharmacology and Pharmaceutical Sciences. Italian Journal of Pediatrics, 44(1), [147]. https://doi.org/10.1186/s13052-018-0589-3