Sialidases in Vertebrates. A Family Of Enzymes Tailored For Several Cell Functions

Eugenio Monti, Erik Bonten, Alessandra D'Azzo, Roberto Bresciani, Bruno Venerando, Giuseppe Borsani, Roland Schauer, Guido Tettamanti

Research output: Contribution to journalArticle

Abstract

This review summarizes the recent research development on vertebrate sialidase biology. Sialic acid-containing compounds play important roles in many physiological processes, including cell proliferation, apoptosis and differentiation, control of cell adhesion, immune surveillance, and clearance of plasma proteins. In this context, sialidases, the glycohydrolases that remove the terminal sialic acid at the non-reducing end of various glycoconjugates, perform an equally pivotal function. Sialidases in higher organisms are differentially expressed in cells and tissues/organs, with particular subcellular distribution and substrate specificity: they are the lysosomal (NEU1), the cytosolic (NEU2), and plasma membrane- and intracellular-associated sialidases (NEU3 and NEU4). The molecular cloning of several mammalian sialidases since 1993 has boosted research in this field. Here we summarize the results obtained since 2002, when the last general review on the molecular biology of mammalian sialidases was written. In those few years many original papers dealing with different aspects of sialidase biology have been published, highlighting the increasing relevance of these enzymes in glycobiology. Attention has also been paid to the trans-sialidases, which transfer sialic acid residues from a donor sialoconjugate to an acceptor asialo substrate. These enzymes are abundantly distributed in trypanosomes and employed to express pathogenicity, also in humans. There are structural similarities and strategic differences at the level of the active site between the mammalian sialidases and trans-sialidases. A better knowledge of these properties may permit the design of better anti-pathogen drugs.

Original languageEnglish
Pages (from-to)404-479
Number of pages76
JournalAdvances in Carbohydrate Chemistry and Biochemistry
Volume64
Issue numberC
DOIs
Publication statusPublished - 2010

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N-Acetylneuraminic Acid
Vertebrates
Neuraminidase
Enzymes
Glycomics
Physiological Phenomena
Molecular biology
Glycoconjugates
Trypanosomiasis
Cloning
Glycoside Hydrolases
Cell adhesion
Cell proliferation
Molecular Cloning
Pathogens
Substrates
Cell membranes
Substrate Specificity
Research
Cell Adhesion

Keywords

  • Apoptosis
  • Bioinformatic analysis
  • Cell adhesion
  • Cell differentiation
  • Cell-to-cell interaction
  • Crystal structure
  • Elastogenesis
  • Gangliosides
  • Glycoproteins
  • Immune-system modulation
  • Knockout mice
  • Lipid rafts
  • NEU1 deficiency
  • Sialidases
  • Signal transduction
  • Subcellular localization
  • Therapeutic application
  • Tissue remodeling
  • Trans-sialidases
  • Tumor cells

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

Monti, E., Bonten, E., D'Azzo, A., Bresciani, R., Venerando, B., Borsani, G., ... Tettamanti, G. (2010). Sialidases in Vertebrates. A Family Of Enzymes Tailored For Several Cell Functions. Advances in Carbohydrate Chemistry and Biochemistry, 64(C), 404-479. https://doi.org/10.1016/S0065-2318(10)64007-3

Sialidases in Vertebrates. A Family Of Enzymes Tailored For Several Cell Functions. / Monti, Eugenio; Bonten, Erik; D'Azzo, Alessandra; Bresciani, Roberto; Venerando, Bruno; Borsani, Giuseppe; Schauer, Roland; Tettamanti, Guido.

In: Advances in Carbohydrate Chemistry and Biochemistry, Vol. 64, No. C, 2010, p. 404-479.

Research output: Contribution to journalArticle

Monti, E, Bonten, E, D'Azzo, A, Bresciani, R, Venerando, B, Borsani, G, Schauer, R & Tettamanti, G 2010, 'Sialidases in Vertebrates. A Family Of Enzymes Tailored For Several Cell Functions', Advances in Carbohydrate Chemistry and Biochemistry, vol. 64, no. C, pp. 404-479. https://doi.org/10.1016/S0065-2318(10)64007-3
Monti, Eugenio ; Bonten, Erik ; D'Azzo, Alessandra ; Bresciani, Roberto ; Venerando, Bruno ; Borsani, Giuseppe ; Schauer, Roland ; Tettamanti, Guido. / Sialidases in Vertebrates. A Family Of Enzymes Tailored For Several Cell Functions. In: Advances in Carbohydrate Chemistry and Biochemistry. 2010 ; Vol. 64, No. C. pp. 404-479.
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