Sindrome secca associata a malattia linfoproliferativa sistemica. Profilo clinico-patologico e sierologico di 11 casi.

Translated title of the contribution: Sicca syndrome associated with systemic lymphoproliferative disease. Clinico-pathologic and serologic profile of 11 cases

M. Longhi, R. Caporali, R. Carnevale, C. M. Montecucco

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical, histologic, and immunohistochemical studies were performed in 11 patients suffering from sicca syndrome with extraglandular lymphoid lesions (liver, spleen, lymph nodes and bone). Seven patients proved to have primary Sjögren's syndrome (SS), 3 had non Hodgkin's lymphoma (NHL) with glandular and extraglandular monoclonal B-cell infiltrates, and 1 had diffuse Castleman's disease (CD). Antibodies to nuclear and/or cytoplasmic ribonucleoproteins were found, by immunodiffusion, in sera from all patients with SS (anti-SSA/Ro in 7 cases and anti-SSB/La in 6). No patient with NHL or CD had evidence of circulating antibodies to these antigens as well as other soluble nuclear antigens. Our data suggests that antibodies to SSA/Ro and SSB/la are strongly associated with extraglandular lymphoid lesions in primary SS and may be useful in differentiating this condition from sicca complex with NHL.

Translated title of the contributionSicca syndrome associated with systemic lymphoproliferative disease. Clinico-pathologic and serologic profile of 11 cases
Original languageItalian
Pages (from-to)297-302
Number of pages6
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume66
Issue number4
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology

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