Sick sinus syndrome: the role of hypervagotonia

Vincenzo Santinelli, Massimo Chiariello, Michele Clarizia, Mario Condorelli

Research output: Contribution to journalArticle


A 58-year-old man with persistent symptomatic sinus bradycardia (52 beats/min) showed a markedly prolonged postpacing pause (3240 msec) after atrial pacing at a cycle of 840 msec. In addition, Wenckebach block occurred following atrial pacing at a cycle length of 700 msec. After atropine (2 mg) postpacing pauses returned to normal value and type I second-degree AV block completely reversed to 1:1 AV conduction until paced rates > 140/min. It may be that in some patients marked and persistent vagal overactivity may predispose to "intrinsic" sinus node dysfunction; in later stages, sinus node function may paradoxically result unaffected by changes in autonomic tone.

Original languageEnglish
Pages (from-to)532-535
Number of pages4
JournalInternational Journal of Cardiology
Issue number4
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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