Side effects of anabolic androgenic steroids abuse

Antonio Bonetti, F. Tirelli, A. Catapano, D. Dazzi, A. Dei Cas, F. Solito, C. Ceda, C. Reverberi, C. Monica, S. Pipitone, G. Elia, M. Spattini, G. Magnati

Research output: Contribution to journalArticle

Abstract

Long-term side effects of high doses of anabolic androgenic steroids self-administration were evaluated in this study. Twenty male bodybuilders, voluntarily starting steroid self-administration, were followed every 6 months over 2 years. Physical examination, haematological, metabolic and endocrine variables, semen analysis, hepatic and prostate ultrasound and echocardiographic evaluations were performed. LH values (baseline 3.43 ± 1.75) were suppressed at 18 (1.98 ± 1.99) (p = 0.026) and 24 (2.43 ± 2.17) (p = 0.026), and FSH (3.95 ± 2.01) at 6 (3.01 ± 2.16) (p = 0.031), 12 (2.45 ± 2.54) (p = 0.029), 18 (2.02 ± 2.29) (p = 0.032) and 24 (3.42 ± 2.64) (p = 0.032) months and SHBG (34.11 ± 10.88) values significantly lowered at 12 (24.81 ± 12.49) (p <0.05), 18 (21.28 ± 11.15) (p <0.01), 24 months (25.42 ± 11.16) (p <0.01). A significant decrease in spermatozoa count (p <0.01), and fertility index (p = 0.01) occurred. HDL-cholesterol (baseline 56.94 ± 13.54) was reduced at 18 (41.86 ± 14.17) (p <0.01) and 24 (43.82 ± 18.67) (p <0.05) months and Apo A-1 at 12 (p <0.001), 18 (p = 0.05) and 24 (p = 0.05) months. The most important long-term adverse effects were lower fertility and the impairment of lipid profile associated with an increased cardiovascular risk.

Original languageEnglish
Pages (from-to)679-687
Number of pages9
JournalInternational Journal of Sports Medicine
Volume29
Issue number8
DOIs
Publication statusPublished - Aug 2008

Keywords

  • Anabolic androgenic steroids
  • Bodybuilders
  • Doping
  • Side effects

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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  • Cite this

    Bonetti, A., Tirelli, F., Catapano, A., Dazzi, D., Dei Cas, A., Solito, F., Ceda, C., Reverberi, C., Monica, C., Pipitone, S., Elia, G., Spattini, M., & Magnati, G. (2008). Side effects of anabolic androgenic steroids abuse. International Journal of Sports Medicine, 29(8), 679-687. https://doi.org/10.1055/s-2007-965808