TY - JOUR
T1 - Side effects of genome structural changes
AU - Reymond, Alexandre
AU - Henrichsen, Charlotte N.
AU - Harewood, Louise
AU - Merla, Giuseppe
PY - 2007/10
Y1 - 2007/10
N2 - The first extensive catalog of structural human variation was recently released. It showed that large stretches of genomic DNA that vary considerably in copy number were extremely abundant. Thus it is conceivable that they play a major role in functional variation. Consistently, genomic insertions and deletions were shown to contribute to phenotypic differences by modifying not only the expression levels of genes within the aneuploid segments but also of normal copy-number neighboring genes. In this report, we review the possible mechanisms behind this latter effect.
AB - The first extensive catalog of structural human variation was recently released. It showed that large stretches of genomic DNA that vary considerably in copy number were extremely abundant. Thus it is conceivable that they play a major role in functional variation. Consistently, genomic insertions and deletions were shown to contribute to phenotypic differences by modifying not only the expression levels of genes within the aneuploid segments but also of normal copy-number neighboring genes. In this report, we review the possible mechanisms behind this latter effect.
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U2 - 10.1016/j.gde.2007.08.009
DO - 10.1016/j.gde.2007.08.009
M3 - Article
C2 - 17913489
AN - SCOPUS:35648970050
VL - 17
SP - 381
EP - 386
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
IS - 5
ER -