Side effects of the catechol-O-methyl-transferase inhibitor Ro 40-7592 in rabbits

J. M. Garrido, M. A. Mena, C. Correa, O. Herraras, P. Jorge, K. Leenders, A. Antonini, I. Gunther, M. Psylla, J. G. De Yebenes

Research output: Contribution to journalArticle

Abstract

Catechol-O-methyl-transferase inhibitors are promising drugs in Parkinson's disease since these drugs enhance levodopa effects and increase their duration. However, since these compounds block a pathway for the peripheral metabolism of catecholamines, they may also produce side effects related to elevation of catecholamines in plasma. We investigated the adverse effects of Ro 40-7592 in rabbits and the relationship of Ro 40-7592 to norepinephrine plasma levels. Intravenous administration of Ro 40-7592 in rabbits induced elevation of norepinephrine plasma levels in old animals after bolus injection of a dose three times the highest dose actually recommended to be taken orally by humans. Though Ro 40-7592 appears safe for humans, special precautions may be needed in patients with a high risk of adrenergic hyperactivity.

Original languageEnglish
Pages (from-to)270-276
Number of pages7
JournalClinical Neuropharmacology
Volume17
Issue number3
Publication statusPublished - 1994

Keywords

  • COMT inhibitors
  • Norepinephrine
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Garrido, J. M., Mena, M. A., Correa, C., Herraras, O., Jorge, P., Leenders, K., Antonini, A., Gunther, I., Psylla, M., & De Yebenes, J. G. (1994). Side effects of the catechol-O-methyl-transferase inhibitor Ro 40-7592 in rabbits. Clinical Neuropharmacology, 17(3), 270-276.